ArticleNeurobiology of disease2010
Vulnerability of postnatal hippocampal neurons to seizures varies regionally with their maturational stage.
Article in Neurobiology of disease, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 50 citations in OpenAlex.
- Mechanisms of Organophosphate Toxicity and the Role of Acetylcholinesterase Inhibition.Toxics · 2023Review
- Status epilepticus and early development: Neuronal injury, neurodegeneration, and their consequences.Epilepsia open · 2023Review
- Introduction to the special issue on status epilepticus: neuronal injury, plasticity, and therapies; Celebrating the legacy of Dr. Claude G. Wasterlain.Epilepsia open · 2023Article
- The outcome of early life status epilepticus-lessons from laboratory animals.Epilepsia open · 2023Article
- Microglia and status epilepticus in the immature brain.Epilepsia open · 2023Review
- Morphological study of the postnatal hippocampal development in the TRPV1 knockout mice.Temperature (Austin, Tex.) · 2023Article
- Long-Term Effects of Early Life Seizures on Endogenous Local Network Activity of the Mouse Neocortex.Frontiers in synaptic neuroscience · 2018Article
- Epigenetic suppression of hippocampal calbindin-D28k by ΔFosB drives seizure-related cognitive deficits.Nature medicine · 2017Article
- Simultaneous triple therapy for the treatment of status epilepticus.Neurobiology of disease · 2017Article
- Midazolam-ketamine dual therapy stops cholinergic status epilepticus and reduces Morris water maze deficits.Epilepsia · 2016Article
- Widespread neuronal injury in a model of cholinergic status epilepticus in postnatal day 7 rat pups.Epilepsy research · 2016Article
- An Early and Robust Activation of Caspases Heads Cells for a Regulated Form of Necrotic-like Cell Death.The Journal of biological chemistry · 2015Article
- Differentiating neurons derived from human umbilical cord blood stem cells work as a test system for developmental neurotoxicity.Molecular neurobiology · 2015Article
- Synergistic roles for G-protein γ3 and γ7 subtypes in seizure susceptibility as revealed in double knock-out mice.The Journal of biological chemistry · 2012Article
- Translocation of the serine protease Omi/HtrA2 from mitochondria into the cytosol upon seizure-induced hippocampal injury in the neonatal rat brain.Neurochemical research · 2010Article
- Brain energy metabolism during experimental neonatal seizures.Neurochemical research · 2010Article
- Is neuronal death necessary for acquired epileptogenesis in the immature brain?Epilepsy currents · 2010Article
- Distinct caspase pathways mediate necrosis and apoptosis in subpopulations of hippocampal neurons after status epilepticus.Epilepsia · 2010Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
The mechanism of status epilepticus-induced neuronal death in the immature brain is not fully understood. In the present study, we examined the contribution of caspases in our lithium-pilocarpine model of status epilepticus in 14 days old rat pups. In CA1, upregulation of caspase-8, but not caspase-9, preceded caspase-3 activation in morphologically necrotic cells. Pretreatment with a pan-caspase inhibitor provided neuroprotection, showing that caspase activation was not an epiphenomenon but contributed to neuronal necrosis. By contrast, upregulation of active caspase-9 and caspase-3, but not caspase-8, was detected in apoptotic dentate gyrus neurons, which were immunoreactive for doublecortin and calbindin-negative, two features of immature neurons. These results suggest that, in cells which are aligned in series as parts of the same excitatory hippocampal circuit, the same seizures induce neuronal death through different mechanisms. The regional level of neuronal maturity may be a determining factor in the execution of a specific death program.
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Registered trials
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