ReviewFEBS letters2009
Qualitatively distinct phenotypes in the design space of biochemical systems.
Review in FEBS letters, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed.
- Using monoids for the integration of genomic and metabolic parameters in the prediction of phenotypes in regulatory cascades.Bio Systems · 2025Article
- Using Monoids for the Integration of Genomic and Metabolic Parameters in the Prediction of Phenotypes in Regulatory Cascades.bioRxiv : the preprint server for biology · 2025Article
- Phenotype Design Space Provides a Mechanistic Framework Relating Molecular Parameters to Phenotype Diversity Available for Selection.Journal of molecular evolution · 2023Article
- The best models of metabolism.Wiley interdisciplinary reviews. Systems biology and medicine · 2017Review
- Rapid Discrimination Among Putative Mechanistic Models of Biochemical Systems.Scientific reports · 2016Article
- Model-based genotype-phenotype mapping used to investigate gene signatures of immune sensitivity and resistance in melanoma micrometastasis.Scientific reports · 2016Article
- Design Space Toolbox V2: Automated Software Enabling a Novel Phenotype-Centric Modeling Strategy for Natural and Synthetic Biological Systems.Frontiers in genetics · 2016Article
- Unrelated toxin-antitoxin systems cooperate to induce persistence.Journal of the Royal Society, Interface · 2015Article
- Genetic simulation tools for post-genome wide association studies of complex diseases.Genetic epidemiology · 2015Article
- Strategy revealing phenotypic differences among synthetic oscillator designs.ACS synthetic biology · 2014Article
- Molecular mechanisms of multiple toxin-antitoxin systems are coordinated to govern the persister phenotype.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
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- Article
- Design of the lac gene circuit revisited.Mathematical biosciences · 2011Review
- Biomedical engineering strategies in system design space.Annals of biomedical engineering · 2011Review
- Phenotypic repertoire of the FNR regulatory network in Escherichia coli.Molecular microbiology · 2011Article
- Automated construction and analysis of the design space for biochemical systems.Bioinformatics (Oxford, England) · 2010Article
- Relating mutant genotype to phenotype via quantitative behavior of the NADPH redox cycle in human erythrocytes.PloS one · 2010Article
- Elucidating the genotype-phenotype map by automatic enumeration and analysis of the phenotypic repertoire.NPJ systems biology and applicationsArticle
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Although characterization of the genotype has undergone revolutionary advances as a result of the successful genome projects, the chasm between our understanding of a fully characterized gene sequence and the phenotypic repertoire of the organism is as broad and deep as it was in the pre-genomic era. There are two fundamental unsolved problems that provide the context for the challenges in relating genotype to phenotype. We address one of these and describe a generic method for constructing a system design space in which qualitatively distinct phenotypes can be identified and counted, their relative fitness analyzed and compared, and their tolerance to change measured.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.