ArticleThe journal of pain2009
Role of NFkappaB in an animal model of complex regional pain syndrome-type I (CRPS-I).
Article in The journal of pain, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07259382 (Neuro-Inflammation in Extremity Trauma), which is not on this map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neuro-Inflammation in Extremity Trauma: Risk Verification in Elbow Trauma: The NERVE Pilot Cohort Study
Who cites it
24 citing papers in PubMed, 64 citations in OpenAlex.
- Botulinum Toxin Type A Reduces Pain and NF-κB Levels in a Rat Model of Complex Regional Pain Syndrome.Journal of pain research · 2026Article
- The Effect of Super-Repressor IkB-Loaded Exosomes (Exo-srIκBs) in Chronic Post-Ischemia Pain (CPIP) Models.Pharmaceutics · 2023Article
- Preoperative Predictors of Complex Regional Pain Syndrome Outcomes in the 6 Months Following Total Knee Arthroplasty.The journal of pain · 2022Observational
- Preventive Supplementation of Omega-3 Reduces Pain and Pro-inflammatory Cytokines in a Mouse Model of Complex Regional Pain Syndrome Type I.Frontiers in integrative neuroscience · 2022Article
- Possible Therapeutic Options for Complex Regional Pain Syndrome.Biomedicines · 2021Article
- [Effect and mechanism of glycyrrhizin on glial scar formation after spinal cord injury in rats].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2020Article
- Increased calcium-mediated cerebral processes after peripheral injury: possible role of the brain in complex regional pain syndrome.The Korean journal of pain · 2020Article
- DNA methylation profiles are associated with complex regional pain syndrome after traumatic injury.Pain · 2019Article
- Increased cerebral nuclear factor kappa B in a complex regional pain syndrome rat model: possible relationship between peripheral injury and the brain.Journal of pain research · 2019Article
- Anti-allodynic Effect of Mangiferin in Rats With Chronic Post-ischemia Pain: A Model of Complex Regional Pain Syndrome Type I.Frontiers in pharmacology · 2018Article
- NF-KappaB Pathway Is Involved in Bone Marrow Stromal Cell-Produced Pain Relief.Frontiers in integrative neuroscience · 2018Article
- Effect of dexmedetomidine on the development of mechanical allodynia and central sensitization in chronic post-ischemia pain rats.Journal of pain research · 2018Article
- The Therapeutic Effect of Vitamin C in an Animal Model of Complex Regional Pain Syndrome Produced by Prolonged Hindpaw Ischemia-Reperfusion in Rats.International journal of medical sciences · 2017Article
- Regulation of proinflammatory genes by the circulating microRNA hsa-miR-939.Scientific reports · 2016Article
- Minocycline attenuates bone cancer pain in rats by inhibiting NF-κB in spinal astrocytes.Acta pharmacologica Sinica · 2016Article
- Hypoxia-induced sensitisation of TRPA1 in painful dysesthesia evoked by transient hindlimb ischemia/reperfusion in mice.Scientific reports · 2016Article
- Acute and chronic nociceptive phases observed in a rat hind paw ischemia/reperfusion model depend on different mechanisms.Pflugers Archiv : European journal of physiology · 2016Article
- Article
- Effects of pinacidil on changes to the microenvironment around the incision site, of a skin/muscle incision and retraction, in a rat model of postoperative pain.Molecular medicine reports · 2015Article
- Activation of spinal NF-КB mediates pain behavior induced by plantar incision.International journal of clinical and experimental medicine · 2015Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
unlabelledNFkappaB is involved in several pathogenic mechanisms that are believed to underlie the complex regional pain syndrome (CRPS), including ischemia, inflammation and sensitization. Chronic postischemia pain (CPIP) has been developed as an animal model that mimics the symptoms of CRPS-I. The possible involvement of NFkappaB in CRPS-I was studied using CPIP rats. Under sodium pentobarbital anesthesia, a tourniquet was placed around the rat left ankle joint, producing 3 hours of ischemia, followed by rapid reperfusion (IR injury). NFkappaB was measured in nuclear extracts of muscle and spinal cord tissue using ELISA. Moreover, the anti-allodynic (mechanical and cold) effect was tested for systemic, intrathecal, or intraplantar treatment with the NFkappaB inhibitor pyrrolidine dithiocarbamate (PDTC). At 2 and 48 hours after IR injury, NFkappaB was elevated in muscle and spinal cord of CPIP rats compared to shams. At 7 days, NFkappaB levels were normalized in muscle, but still elevated in spinal cord tissue. Systemic PDTC treatment relieved mechanical and cold allodynia in a dose-dependent manner, lasting for at least 3 hours. Intrathecal-but not intraplantar-administration also relieved mechanical allodynia. The results suggest that muscle and spinal NFkappaB plays a role in the pathogenesis of CPIP and potentially of human CRPS. PERSPECTIVE: Using the CPIP model, we demonstrate that NFkappaB is involved in the development of allodynia after a physical injury (ischemia and reperfusion) without direct nerve trauma. Since CPIP animals exhibit many features of human CRPS-I, this observation indicates a potential role for NFkappaB in human CRPS.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.