ArticleBMC genomics2009
EST and microarray analysis of horn development in Onthophagus beetles.
Article in BMC genomics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 45 citations in OpenAlex.
- Transcriptomic basis underlying the evolution of female horn plasticity in scarab beetles.Frontiers in zoology · 2026Article
- Male Reproductive Traits Display Increased Phenotypic Variation in Response to Resource Quality and Parental Provisioning in a Tropical Rainforest Dung Beetle,Ecology and evolution · 2024Article
- The Genetic Basis Underpinning Sexually Selected Traits across Different Animal Lineages: Are There Genetic Mechanisms in Common?Animals : an open access journal from MDPI · 2024Review
- Notch Signaling in Insect Development: A Simple Pathway with Diverse Functions.International journal of molecular sciences · 2023Review
- Sexual size dimorphism and male reproductive traits vary across populations of a tropical rainforest dung beetle species (Ecology and evolution · 2022Article
- Notch signaling patterns head horn shape in the bull-headed dung beetle Onthophagus taurus.Development genes and evolution · 2020Article
- Article
- The origins of novelty from within the confines of homology: the developmental evolution of the digging tibia of dung beetles.Proceedings. Biological sciences · 2019Article
- Article
- The transcriptomic basis of tissue- and nutrition-dependent sexual dimorphism in the beetle Onthophagus taurus.Ecology and evolution · 2016Article
- The right tools for the job: Regulating polyphenic morph development in insects.Current opinion in insect science · 2016Article
- Are Horn Morphological Patterns Able to Differentiate the Two Closely Related Species Copris klugi Harold and Copris sierrensis Matthews?Neotropical entomology · 2015Article
- The nutritionally responsive transcriptome of the polyphenic beetle Onthophagus taurus and the importance of sexual dimorphism and body region.Proceedings. Biological sciences · 2014Article
- Insights into the development and evolution of exaggerated traits using de novo transcriptomes of two species of horned scarab beetles.PloS one · 2014Article
- Diversification of doublesex function underlies morph-, sex-, and species-specific development of beetle horns.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Fine scale analysis of gene expression in Drosophila melanogaster gonads reveals Programmed cell death 4 promotes the differentiation of female germline stem cells.BMC developmental biology · 2012Article
- Insulin signaling as a mechanism underlying developmental plasticity: the role of FOXO in a nutritional polyphenism.PloS one · 2012Article
- Epigenetic mechanisms underlying developmental plasticity in horned beetles.Genetics research international · 2012Article
- Developmental decoupling of alternative phenotypes: insights from the transcriptomes of horn-polyphenic beetles.Evolution; international journal of organic evolution · 2011Article
- Gene discovery in the horned beetle Onthophagus taurus.BMC genomics · 2010Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe origin of novel traits and their subsequent diversification represent central themes in evo-devo and evolutionary ecology. Here we explore the genetic and genomic basis of a class of traits that is both novel and highly diverse, in a group of organisms that is ecologically complex and experimentally tractable: horned beetles.
resultsWe developed two high quality, normalized cDNA libraries for larval and pupal Onthophagus taurus and sequenced 3,488 ESTs that assembled into 451 contigs and 2,330 singletons. We present the annotation and a comparative analysis of the conservation of the sequences. Microarrays developed from the combined libraries were then used to contrast the transcriptome of developing primordia of head horns, prothoracic horns, and legs. Our experiments identify a first comprehensive list of candidate genes for the evolution and diversification of beetle horns. We find that developing horns and legs show many similarities as well as important differences in their transcription profiles, suggesting that the origin of horns was mediated partly, but not entirely, by the recruitment of genes involved in the formation of more traditional appendages such as legs. Furthermore, we find that horns developing from the head and prothorax differ in their transcription profiles to a degree that suggests that head and prothoracic horns are not serial homologs, but instead may have evolved independently from each other.
conclusionWe have laid the foundation for a systematic analysis of the genetic basis of horned beetle development and diversification with the potential to contribute significantly to several major frontiers in evolutionary developmental biology.
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