Evidence map›Paper›PMID 19878229›Full record

ReviewClinical & experimental ophthalmology2009

New era for personalized medicine: the diagnosis and management of age-related macular degeneration.

Paul N Baird, Gregory S Hageman, Robyn H Guymer

Open access · greenAbstract readReview
In one paragraph

Review in Clinical & experimental ophthalmology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
4.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 31 citations in OpenAlex.

  1. Patient characteristics and treatment of neovascular age-related macular degeneration in France: the LUEUR1 observational study.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2011
    Trial
  2. Review
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  5. Review
  6. Article
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  9. Genetic diversity and medicinal drug response in eye care.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2010
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 2 countries.

Paul N BairdCentre for Eye Research Australia, University of Melbourne, Royal Victorian Eye and Ear Hospital, East Melbourne, Victoria, Australia. pnb@unimelb.edu.au
Gregory S Hageman
Robyn H Guymer
Centre for Eye Research Australia · AUUniversity of Iowa · USUniversity of Melbourne · AU

Funding

Development of Complement Modulating Therapeutics for AMDR24EY017404 · NEI · UNIVERSITY OF UTAH · PI HAGEMAN, GREGORY S · 2006 to 2010
$14.8M
NEI NIH HHS R24 EY017404
6 · The paper itself

Abstract

It can be argued that age-related macular degeneration is one of the best characterized complex trait diseases. Extensive information related to genetic and environmental risk factors exists, and a number of different biological pathways are strongly implicated in its aetiology. Along with recent improvements in high throughput and relatively inexpensive genetic technologies, we are now in a position to consider developing a presymptomatic, personalized approach towards the assessment, management and treatment of this disease. We explore the applicability and challenges of this approach if it is to become commonplace for guiding treatment decisions for individuals with pre-existing disease or for those at high risk of developing it.

Indexed as

Polymorphism, Single NucleotideGenetic Predisposition to DiseaseHumansMacular DegenerationPrecision MedicineRisk Factors

Identifiers

PMID19878229
PMCPMC4853908
OpenAlexW1979578284

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.