Evidence map›Paper›PMID 19877800›Full record

ArticleAIDS patient care and STDs2009

Factors associated with prevalent hepatitis C infection among HIV-infected women with no reported history of injection drug use: the Women's Interagency HIV Study (WIHS).

Toni Frederick, Pamela Burian, Norah Terrault, Mardge Cohen, Michael Augenbraun, Mary Young, Eric Seaberg, Jessica Justman, Alexandra M Levine, Wendy J Mack and 1 more

Abstract read
In one paragraph

Article in AIDS patient care and STDs, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. High hepatitis C virus prevalence among drug users in Iran: systematic review and meta-analysis of epidemiological evidence (2001-2012).International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2015
    Pooled it
  2. Sexually transmitted diseases treatment guidelines, 2015.MMWR. Recommendations and reports : Morbidity and mortality weekly report. Recommendations and reports · 2015
    Guideline
  3. Article
  4. Article
  5. Article
  6. Article
  7. Intersecting Epidemics: Incident Syphilis and Drug Use in Women Living With Human Immunodeficiency Virus in the United States (2005-2016).Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2020
    Article
  8. Article
  9. Article
  10. Dual sexual and drug-related predictors of hepatitis C incidence among sex workers in a Canadian setting: gaps and opportunities for scale-up of hepatitis C virus prevention, treatment, and care.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2017
    Article
  11. Article
  12. Management of Hepatitis C/HIV Coinfection in the Era of Highly Effective Hepatitis C Virus Direct-Acting Antiviral Therapy.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2016
    Review
  13. Article
  14. Article
  15. Observational
  16. Observational
  17. Article
  18. Incident hepatitis C virus infection in men who have sex with men: a prospective cohort analysis, 1984-2011.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2013
    Article
  19. HCV enters the twenty-first century.Current infectious disease reports · 2013
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Toni FrederickMaternal-Child and Adolescent Center for Infectious Diseases and Virology, University of Southern California, Los Angeles, California, USA. tfrederi@usc.edu
Pamela Burian
Norah Terrault
Mardge Cohen
Michael Augenbraun
Mary Young
Eric Seaberg
Jessica Justman
Alexandra M Levine
Wendy J Mack
Andrea Kovacs

Funding

Women's Interagency HIV Study (WIHS-V)U01AI035004 · NIAID · MONTEFIORE MEDICAL CENTER (BRONX, NY) · PI ANASTOS, KATHRYN M., SHARMA, ANJALI · 1993 to 2018
$65.7M
WOMEN'S INTERAGENCY HIV STUDY ORGANIZATION, MANAGEMENT AND COMMUNICATIONSU01AI034989 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI AOUIZERAT, BRADLEY E, GREENBLATT, RUTH MARTHA · 1993 to 2018
$65.6M
Women's Interagency HIV Study (WIHS) IIIU01AI031834 · NIAID · SUNY DOWNSTATE MEDICAL CENTER · PI GUSTAFSON, DEBORAH R., MINKOFF, HOWARD · 1998 to 2018
$53.5M
WOMEN'S INTERAGENCY HIV STUDY (WIHS) ORGANIZATION AND MANAGEMENTU01AI034994 · NIAID · GEORGETOWN UNIVERSITY · PI KASSAYE, SEBLE G · 1993 to 2018
$52.0M
Women's Interagency HIV Study (WIHS) IV, Chicago ConsortiumU01AI034993 · NIAID · HEKTOEN INSTITUTE FOR MEDICAL RESEARCH · PI COHEN, MARDGE H, FRENCH, AUDREY · 1994 to 2018
$51.0M
ZIPRASIDONE (GEODON) AUGMENTATION IN SEROTONIN REUPTAKE INHIBITOR-RESISTANT OBM01RR000071 · NCRR · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI OHNUMA, TAKAO · 1985 to 2009
$41.5M
WIHS DATA MANAGEMENT AND ANALYSIS CENTER(WDMAC)U01AI042590 · NIAID · JOHNS HOPKINS UNIVERSITY · PI GANGE, STEPHEN J, GOLUB, ELIZABETH T · 1998 to 2018
$38.4M
ZD1839 FOR MALIGNANT ASTROCYTOMA OR GLIOBLASTOMA AND MENINGIOMAM01RR000079 · NCRR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KESSLER, DAVID A · 1985 to 2006
$26.0M
WELFARE REFORM AND THE PERINATAL HEALTH OF IMMIGRANTSM01RR000083 · NCRR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KESSLER, DAVID A · 1985 to 2006
$21.1M
HCV and Progression of HIV and HAART Response in WomenR01AI052065 · NIAID · UNIVERSITY OF SOUTHERN CALIFORNIA · PI KOVACS, ANDREA A.Z. · 2002 to 2011
$6.9M
HIV AND HCV DISEASE PROGRESSION IN WOMEN ON HAARTR56AI052065 · NIAID · UNIVERSITY OF SOUTHERN CALIFORNIA · PI KOVACS, ANDREA A.Z. · 2014 to 2014
$655k
NCRR NIH HHS MO1-RR-00071NCRR NIH HHS MO1-RR-00079NCRR NIH HHS MO1-RR-00083NIAID NIH HHS R01 AI052065NIAID NIH HHS R56 AI052065NIAID NIH HHS UO1-AI-31834NIAID NIH HHS UO1-AI-34989NIAID NIH HHS UO1-AI-34993NIAID NIH HHS UO1-AI-34994NIAID NIH HHS UO1-AI-35004NIAID NIH HHS UO1-AI-42590NICHD NIH HHS UO1-HD-23632
6 · The paper itself

Abstract

Although the primary mode of hepatitis C virus (HCV) transmission is exposure to blood products or injection drug use (IDU), studies have found varying independent risk factors for HCV infection among persons with no history of IDU or exposure to blood products. For HIV-infected women, sexual transmission may be another potential source of HCV infection. HIV-infected and HIV-negative women at risk for HIV enrolled in the Women's Interagency HIV Study (WIHS) during October 1994 to November 1995 and again between October 2001 and November 2002 were studied. Clinical and demographic factors associated with HCV seroprevalence were assessed in multivariate logistic regression models controlling for history of blood transfusion and IDU. Among 3636 women with HCV results, 31.5% were HCV antibody positive (HCV+) including 13.5% with no reported history of IDU or blood transfusions. Multivariate logistic regression analyses stratified on IDU showed that among women with no history of IDU, sex with an IDU male was independently associated with HCV positivity (odds ratio [OR] = 2.8, 95% confidence [CI] = 2.1, 3.8, p < 0.0001) after controlling for blood transfusion, age, HIV infection, unemployment, birth in the United States, history of hepatitis B infection, and current smoking status. Further stratification on HIV status showed that the association was significant only for the HIV+ (OR = 1.9, 95% CI = 1.3, 2.7, p = 0.0007) compared to the HIV- women (OR = 1.1, 95% CI = 0.4, 2.7) although these odds ratios were not significantly different (p = 0.25). For HIV-positive women with no reported history of IDU, sex with an IDU male was independently associated with HCV suggesting that sexual transmission may be an important mode of HCV transmission for these high-risk women.

Indexed as

AdultBlood TransfusionFemaleHepacivirusHepatitis CHepatitis C AntibodiesHIV InfectionsHumansLogistic ModelsMalePrevalenceRisk FactorsSexual BehaviorSexually Transmitted Diseases, ViralSubstance Abuse, IntravenousHepatitis C Antibodies

Identifiers

PMID19877800
PMCPMC2823487

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.