ReviewDrugs2009
Candida colonization and candiduria in critically ill patients in the intensive care unit.
Review in Drugs, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- Clinical Practice Guideline for the Management of Candidiasis: 2016 Update by the Infectious Diseases Society of America.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2016Guideline
- [Candiduria! What now? : Therapy of urinary tract infections with Candida].Der Urologe. Ausg. A · 2017Trial
- Oral nystatin prophylaxis in surgical/trauma ICU patients: a randomised clinical trial.Critical care (London, England) · 2012Trial
- Bridging the gap between guidelines and practice: real-world evaluation of Candida management and outcomes in a Turkish tertiary care center.BMC infectious diseases · 2026Article
- Development of a new clinical prediction rule for candidaemia.BMC infectious diseases · 2026Article
- ISCCM Position Statement on the Management of Invasive Fungal Infections in the Intensive Care Unit.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2024Article
- Management of candiduria in hospitalized patients: a single-center study on the implementation of IDSA guidelines and factors affecting clinical decisions.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2021Article
- Candidemia Following Ureteric Stent Placement in a Patient With Type 2 Diabetes Treated With Canagliflozin.Frontiers in endocrinology · 2019Article
- Editorial: The Risky Business of Fungal Infections in Patients with Cirrhosis.The American journal of gastroenterology · 2018Article
- The role of neutrophils in immune dysfunction during severe inflammation.Critical care (London, England) · 2016Review
- Invasive Candida infections in patients of a medical intensive care unit: attempt of improving diagnosis by quantifying the colonization.Wiener klinische Wochenschrift · 2015Observational
- Risk factors for Candida colonization and Co-colonization with multi-drug resistant organisms at admission.Antimicrobial resistance and infection control · 2015Article
- Antimicrobial Activity Evaluation on Silver Doped Hydroxyapatite/Polydimethylsiloxane Composite Layer.BioMed research international · 2015Article
- Review
- Insights into Candida tropicalis nosocomial infections and virulence factors.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2012Review
- Detection of Candida albicans by mass spectrometric fingerprinting.Current microbiology · 2012Article
- Candida peritonitis: an update on the latest research and treatments.World journal of surgery · 2011Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Clinical severity of invasive candidiasis in critically ill patients and existing difficulties in timely diagnosis mean that early empirical therapy, based upon a strict clinical and epidemiological judgement, is required in intensive care unit patients. One school of thought is that the clinical severity and epidemiological burden of this disease warrant prophylaxis in all critically ill patients. In reality, however, there are still many open-ended questions with regard to which variables are most apt for selection of patients requiring prophylactic or empirical treatment. As a consequence of a consistently significant correlation between colonization (one or more Candida-positive cultures from non-sterile sites) and subsequent infection, colonization remains the most universally accepted predictive variable with regard to invasive candidiasis. This is particularly true for high density colonization. It has not yet been clarified whether colonization can be used in isolation to identify high-risk patients or if it should be combined with other variables indicating high risk. Additionally, there is still a debate surrounding the question as to whether determination of multisite colonization is required, or whether detecting colonization at one or two specific sites is sufficient for the identification of high-risk patients. From a practical perspective, candiduria (a frequent finding in critically ill patients) appears one of the most promising parameters with regard to single-site assessment, owing to easy sampling procedures. Definitive evidence of a correlation between candiduria and invasive candidiasis is currently still lacking, as the few published studies thus far have yielded conflicting results. It is, however, apparent that candiduria can be reliably considered a surrogate marker of high density of colonization, thereby potentially representing a more practical, less resource-intensive screening marker of heavy colonization and high risk of infection than is currently possible using parameters such as the multiple-site colonization index.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.