ReviewDialogues in clinical neuroscience2009
Neurotoxicity of drugs of abuse--the case of methylenedioxyamphetamines (MDMA, ecstasy), and amphetamines.
Review in Dialogues in clinical neuroscience, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 115 citations in OpenAlex.
- Memory-related hippocampal functioning in ecstasy and amphetamine users: a prospective fMRI study.Psychopharmacology · 2013Trial
- Effects of acute MDMA intoxication on mood and impulsivity: role of the 5-HT2 and 5-HT1 receptors.PloS one · 2012Trial
- Bioanalysis of amphetamines in alternative matrices using a sensitive and validated liquid chromatography-tandem mass spectrometry method and its application to real samples.Scientific reports · 2026Article
- Verbal memory dysfunction in substance use and gambling addictive disorders: a comparative analysis of performance accuracy and error typologies.Frontiers in psychology · 2025Article
- MDMA-Based Psychotherapy in Treatment-Resistant Post-Traumatic Stress Disorder (PTSD): A Brief Narrative Overview of Current Evidence.Diseases (Basel, Switzerland) · 2023Review
- Knockout of Dopamine D3 Receptor Gene Blocked Methamphetamine-Induced Distinct Changes of Dopaminergic and Glutamatergic Synapse in the Nucleus Accumbens Shell of Mice.Frontiers in cellular neuroscience · 2022Article
- Typologies of illicit drug use in mid-adulthood: a quasi-longitudinal latent class analysis in a community-based sample of twins.Addiction (Abingdon, England) · 2021Article
- A prospective longitudinal study shows putamen volume is associated with moderate amphetamine use and resultant cognitive impairments.Psychoradiology · 2021Article
- Harm reduction strategies related to dosing and their relation to harms among festival attendees who use multiple drugs.Drug and alcohol review · 2019Article
- Astroglial correlates of neuropsychiatric disease: From astrocytopathy to astrogliosis.Progress in neuro-psychopharmacology & biological psychiatry · 2018Review
- Dark Classics in Chemical Neuroscience: 3,4-Methylenedioxymethamphetamine.ACS chemical neuroscience · 2018Review
- No evidence of subgroups found in amphetamine consumers in Iran.Neuropsychiatrie : Klinik, Diagnostik, Therapie und Rehabilitation : Organ der Gesellschaft Osterreichischer Nervenarzte und Psychiater · 2018Article
- Translational Biomarkers of Neurotoxicity: A Health and Environmental Sciences Institute Perspective on the Way Forward.Toxicological sciences : an official journal of the Society of Toxicology · 2015Review
- A longitudinal study of self-reported psychopathology in early ecstasy and amphetamine users.Psychopharmacology · 2015Article
- Keto amphetamine toxicity-focus on the redox reactivity of the cathinone designer drug mephedrone.Toxicological sciences : an official journal of the Society of Toxicology · 2014Article
- A single neurotoxic dose of methamphetamine induces a long-lasting depressive-like behaviour in mice.Neurotoxicity research · 2014Article
- Translational toxicology: a developmental focus for integrated research strategies.BMC pharmacology & toxicology · 2013Article
- 3,4-methylenedioxymethamphetamine (MDMA): current perspectives.Substance abuse and rehabilitation · 2013Review
- Sex-dependent psychoneuroendocrine effects of THC and MDMA in an animal model of adolescent drug consumption.PloS one · 2013Article
- D1/NMDA receptors and concurrent methamphetamine+ HIV-1 Tat neurotoxicity.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ecstasy (MDMA, 3,4-methylendioxymethamphetamine) and the stimulants methamphetamine (METH, speed) and amphetamine are popular drugs among young people, particularly in the dance scene. When given in high doses both MDMA and the stimulant amphetamines are clearly neurotoxic in laboratory animals. MDMA causes selective and persistent lesions of central serotonergic nerve terminals, whereas amphetamines damage both the serotonergic and dopaminergic systems. In recent years, the question of ecstasy-induced neurotoxicity and possible functional sequelae has been addressed in several studies in drug users. Despite large methodological problems, the bulk of evidence suggests residual alterations of serotonergic transmission in MDMA users, although at least partial recovery may occur after long-term abstinence. However, functional sequelae may persist even after longer periods of abstinence. To date, the most consistent findings associate subtle cognitive impairments with ecstasy use, particularly with memory. In contrast, studies on possible long-term neurotoxic effects of stimulant use have been relatively scarce. Preliminary evidence suggests that alterations of the dopaminergic system may persist even after years of abstinence from METH, and may be associated with deficits in motor and cognitive performance. In this paper, we will review the literature focusing on human studies.
Indexed as
Identifiers
19877498PMC3181923W1486304586What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.