ArticleDevelopmental dynamics : an official publication of the American Association of Anatomists2009
Characterization of the expression pattern of the PRC2 core subunit Suz12 during embryonic development of Xenopus laevis.
Article in Developmental dynamics : an official publication of the American Association of Anatomists, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed, 13 citations in OpenAlex.
- Neural is Fundamental: Neural Stemness as the Ground State of Cell Tumorigenicity and Differentiation Potential.Stem cell reviews and reports · 2022Review
- Building a Mammalian Retina: An Eye on Chromatin Structure.Frontiers in genetics · 2021Review
- Transcriptional Regulation of Arabidopsis Polycomb Repressive Complex 2 Coordinates Cell-Type Proliferation and Differentiation.The Plant cell · 2016Article
- Snail2/Slug cooperates with Polycomb repressive complex 2 (PRC2) to regulate neural crest development.Development (Cambridge, England) · 2015Article
- Article
- Polycomb repressive complex PRC2 regulates Xenopus retina development downstream of Wnt/β-catenin signaling.Development (Cambridge, England) · 2013Article
- PRC2 during vertebrate organogenesis: a complex in transition.Developmental biology · 2012Review
- Geminin cooperates with Polycomb to restrain multi-lineage commitment in the early embryo.Development (Cambridge, England) · 2011Article
- Stage-specific histone modification profiles reveal global transitions in the Xenopus embryonic epigenome.PloS one · 2011Article
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Authors and funding
2 authors at 1 institution in 1 country.
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Abstract
The Polycomb repressive complex 2 is a multimeric aggregate that mediates silencing of a broad range of genes, and is associated with important biological contexts such as stem cell maintenance and cancer progression. PRC2 mainly trimethylates lysine 27 of histone H3 and is composed of three essential core subunits: EZH2, EED, and SUZ12. The Xenopus orthologs of PRC2 subunits Ezh2 and Eed have been described but Suz12 remained unidentified. Here, we report the cloning of the Xenopus Suz12, and determine its spatiotemporal expression during development. Xsuz12 transcript is provided maternally and continues to be expressed throughout development, particularly in the anterior part of the developing central nervous system. Importantly, comparative analysis of the expression of the PRC2 subunits Xez, Xeed, and Xrbbp4 indicates that their expression largely coincides with Xsuz12 in the nervous system, suggesting that PRC2 may have unexplored functions in the development of the frog central nervous system.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.