ArticleThe International journal of developmental biology2010
The surface area of the placenta and hypertension in the offspring in later life.
Article in The International journal of developmental biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06275438 (Comparison of Oxytocin Receptor Immunoreactivity in Placentas Obtained From Women Having Cesarean and Natural Birth), which is not on this map. Cited by 75 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Comparison of Oxytocin Receptor Immunoreactivity in Placentas Obtained From Women Having Cesarean and Natural Birth
Who cites it
75 citing papers in PubMed, 213 citations in OpenAlex.
- Trial
- Inhibition of p65 nuclear translocation in decidual stromal cells underlies COS-induced supraphysiologic estrogen impairment of uNK cell function which drives placental abnormalities.Journal of translational medicine · 2026Article
- Perinatal Endocrine-Cardiac Axis: A Narrative Review of Long-Term Cardiovascular Risks in Women with Gestational Diabetes, Hypertensive Disorders, and Thyroid Dysfunction.Biomedicines · 2026Review
- Applying AI models to digital placental photographs to automate and improve morphology assessments.medRxiv : the preprint server for health sciences · 2026Article
- Placental Pathology and Blood Pressure at Age 7: A Longitudinal Discordant Twin Analysis.Arteriosclerosis, thrombosis, and vascular biology · 2025Article
- The causal effects of placental weight on atherosclerotic cardiovascular disease: a Mendelian randomization and mediation analysis.Archives of medical science : AMS · 2025Article
- Cross-modal contrastive learning for unified placenta analysis using photographs.Patterns (New York, N.Y.) · 2024Article
- Maternal-fetal cross-talk via the placenta: influence on offspring development and metabolism.Development (Cambridge, England) · 2023Review
- Article
- Placental morphological features of small for gestational age preterm neonates born to mothers with pregnancy-induced hypertension.Frontiers in pediatrics · 2023Article
- Placental morphology in association with autism-related traits in the EARLI study.BMC pregnancy and childbirth · 2022Article
- Fully Automated Placental Volume Quantification From 3D Ultrasound for Prediction of Small-for-Gestational-Age Infants.Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine · 2022Article
- Volumetric Parameterization of the Placenta to a Flattened Template.IEEE transactions on medical imaging · 2022Article
- The Consequences of Assisted Reproduction Technologies on the Offspring Health Throughout Life: A Placental Contribution.Frontiers in cell and developmental biology · 2022Review
- Impact of vitamin C supplementation on placental DNA methylation changes related to maternal smoking: association with gene expression and respiratory outcomes.Clinical epigenetics · 2021Article
- Placental outcomes of phthalate exposure.Reproductive toxicology (Elmsford, N.Y.) · 2021Review
- Methodology for Biometrical Analysis of the Placenta: Feasibility and Reproducibility.Reproductive sciences (Thousand Oaks, Calif.) · 2021Article
- Pregnancy Complications, Correlation With Placental Pathology and Neonatal Outcomes.Frontiers in clinical diabetes and healthcare · 2021Article
- Associations between the activity of placental nutrient-sensing pathways and neonatal and postnatal metabolic health: the ECHO Healthy Start cohort.International journal of obesity (2005) · 2020Observational
- Quantification of Wave Reflection in the Human Umbilical Artery From Asynchronous Doppler Ultrasound Measurements.IEEE transactions on medical imaging · 2020Article
15 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 4 institutions in 3 countries.
Funding
Abstract
Hypertension is more common among people who had low birthweight. Birthweight depends on the mothers body size and on the growth of the placenta. We studied a group of 2003 subjects, of whom 644 were being treated for hypertension. They were born during 1934-44 in a hospital that kept detailed records of maternal and placental size. Hypertension was associated with reduced placental weight and surface area. These associations were strongest in the offspring of mothers with below average height or low socioeconomic status. In people whose mothers had below average height (160 cm) the prevalence of hypertension fell from 38% if the placental area was 200 cm(2) or less to 21% if the area was more than 320 cm(2) (p=0.0007). In the offspring of tall, middle class mothers, who were likely to have been the best nourished, hypertension was predicted by large placental weight in relation to birthweight. The odds ratio rose from 1.0 if the ratio of placental weight to birthweight was 0.17 or less to 1.9 (95% confidence interval 0.8 to 5.0) if the ratio was more than 0.21 (p for trend =0.03). We conclude that the effects of placental area on hypertension depend on the mothers nutritional state. Poor maternal nutrition may compound the adverse effects of small placental size. In better-nourished mothers the placental surface may expand to compensate for fetal undernutrition. Growth along the minor axis of the surface may be more nutritionally sensitive than growth along the major axis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.