ArticleThe International journal of developmental biology2010
Split immunological tolerance to trophoblast.
Article in The International journal of developmental biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
24 citing papers in PubMed, 66 citations in OpenAlex.
- Comparative analysis of the transcriptome and methylome in distinct trophoblast populations at the time of embryo implantation in mares.BMC genomics · 2026Article
- Contributions of large and agricultural animal models to immunology.Journal of immunology (Baltimore, Md. : 1950) · 2025Review
- Shifts between pro-inflammatory and anti-inflammatory profiles in pregnant mares: a review of physiological functions.Frontiers in veterinary science · 2025Review
- Populations of NK Cells and Regulatory T Cells in the Endometrium of Cycling Mares-A Preliminary Study.Animals : an open access journal from MDPI · 2022Article
- Synergies of Extracellular Vesicles and Microchimerism in Promoting Immunotolerance During Pregnancy.Frontiers in immunology · 2022Review
- Evolution of Placental Hormones: Implications for Animal Models.Frontiers in endocrinology · 2022Review
- Utero-Placental Immune Milieu during Normal and Aglepristone-Induced Parturition in the Dog.Animals : an open access journal from MDPI · 2021Article
- Differential Signals From TNFα-Treated and Untreated Embryos in Uterine Tissues and Splenic CD4Frontiers in veterinary science · 2021Article
- Equine pregnancy-specific glycoprotein CEACAM49 secreted by endometrial cup cells activates TGFB.Reproduction (Cambridge, England) · 2020Article
- Dynamic changes in gene expression and signalling during trophoblast development in the horseReproduction (Cambridge, England) · 2018Article
- Changes in Blood Lymphocyte Subpopulations and Expression of MHC-II Molecules in Wild Mares Before and After Parturition.Journal of veterinary research · 2017Article
- Ectopic Trophoblast Allografts in the Horse Resist Destruction by Secondary Immune Responses.Biology of reproduction · 2016Article
- CD80 and CD86 costimulatory molecules differentially regulate OT-II CD4⁺ T lymphocyte proliferation and cytokine response in cocultures with antigen-presenting cells derived from pregnant and pseudopregnant mice.Mediators of inflammation · 2014Article
- Major histocompatibility complex I mediates immunological tolerance of the trophoblast during pregnancy and may mediate rejection during parturition.Mediators of inflammation · 2014Review
- Characterization of the Th profile of the bovine endometrium during the oestrous cycle and early pregnancy.PloS one · 2013Article
- The equine endometrial cup reaction: a fetomaternal signal of significance.Annual review of animal biosciences · 2013Review
- Generation and characterization of monoclonal antibodies to equine NKp46.Veterinary immunology and immunopathology · 2012Article
- IL-22 is expressed by the invasive trophoblast of the equine (Equus caballus) chorionic girdle.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- Article
- Generation and characterization of monoclonal antibodies to equine CD16.Veterinary immunology and immunopathology · 2012Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Split immunological tolerance refers to states in which an individual is capable of mounting certain types of immune responses to a particular antigenic challenge, but is tolerant of the same antigen in other compartments of the immune system. This concept is applicable to the immunological relationship between mother and fetus, and particularly relevant in equine pregnancy. In pregnant mares, antibody responses to paternal foreign Major Histocompatibility Complex class I antigens are robust, while anti-paternal cytotoxic T cell responses are diminished compared to those mounted by non-pregnant mares. Here, we compared the distribution of the major lymphocyte subsets, the percentage of lymphocytes expressing Interferon Gamma (IFNG) and Interleukin 4 (IL4) and the level of expression of the immunoregulatory transcription factor FOXP3 between pregnant and non-pregnant mares, and between peripheral blood and the endometrium during pregnancy. In a cohort of mares in which peripheral blood lymphocytes were tested during early pregnancy and in the non-pregnant state, there were only slight changes observed during pregnancy. In contrast, comparison of peripheral blood lymphocytes with lymphocytes isolated from the endometrial cups of pregnant mares revealed striking differences in lymphocyte sub-populations. The endometrial cups contained higher numbers of IFNG+ lymphocytes, and lower numbers of lymphocytes expressing IL4. The endometrial cup lymphocytes also had higher numbers of FOXP3+ cells compared to peripheral blood lymphocytes. Taken together, these results strengthen the evidence for a state of split tolerance to trophoblast, and furthermore define sharp differences in immune reactivity during equine pregnancy between peripheral blood lymphocytes and lymphocytes at the maternal-fetal interface.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.