ReviewThe International journal of developmental biology2010
The hidden maternal-fetal interface: events involving the lymphoid organs in maternal-fetal tolerance.
Review in The International journal of developmental biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
30 citing papers in PubMed, 58 citations in OpenAlex.
- Differential modulation of gestational immunity by fatty acids: tissue-specific immune remodeling and clinical implications.Clinical science (London, England : 1979) · 2026Article
- The maternal-fetal interface at single-cell resolution: uncovering the cellular anatomy of the placenta and decidua.American journal of obstetrics and gynecology · 2025Review
- Immunosequencing and Profiling of T Cells at the Maternal-Fetal Interface of Women with Preterm Labor and Chronic Chorioamnionitis.Journal of immunology (Baltimore, Md. : 1950) · 2023Article
- Oxygen regulates ILC3 antigen presentation potential and pregnancy-related hormone actions.Reproductive biology and endocrinology : RB&E · 2022Article
- The immunobiology of preterm labor and birth: intra-amniotic inflammation or breakdown of maternal-fetal homeostasis.Reproduction (Cambridge, England) · 2022Review
- Mesenchymal stromal cell-derived extracellular vesicle therapy prevents preeclamptic physiology through intrauterine immunomodulation†.Biology of reproduction · 2021Article
- Expression of Immune Checkpoint Receptors in Placentae With Infectious and Non-Infectious Chronic Villitis.Frontiers in immunology · 2021Article
- Maternal and fetal T cells in term pregnancy and preterm labor.Cellular & molecular immunology · 2020Review
- The Role of B7 Family Molecules in Maternal-Fetal Immunity.Frontiers in immunology · 2020Review
- Transcriptomic analysis of vitamin D responses in uterine and peripheral NK cells.Reproduction (Cambridge, England) · 2019Article
- Disruption in the Regulation of Immune Responses in the Placental Subtype of Preeclampsia.Frontiers in immunology · 2018Review
- Immune response to a model shared placenta/tumor-associated antigen reduces cancer risk in parous mice.Biology of reproduction · 2017Article
- Trophoblast-microbiome interaction: a new paradigm on immune regulation.American journal of obstetrics and gynecology · 2015Review
- Elevated levels of dehydroepiandrosterone as a potential mechanism of dendritic cell impairment during pregnancy.BMC immunology · 2015Article
- Regulatory T cells and the immune pathogenesis of prenatal infection.Reproduction (Cambridge, England) · 2013Review
- Physiological and molecular determinants of embryo implantation.Molecular aspects of medicine · 2013Review
- Mechanisms of T cell tolerance towards the allogeneic fetus.Nature reviews. Immunology · 2013Review
- The influence of maternal prenatal and early childhood nutrition and maternal prenatal stress on offspring immune system development and neurodevelopmental disorders.Frontiers in neuroscience · 2013Article
- Immunomodulatory molecules are released from the first trimester and term placenta via exosomes.Placenta · 2012Article
- Comprehensive analysis of genes expressed by rare microchimeric fetal cells in the maternal mouse lung.Biology of reproduction · 2012Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
The genetic disparity between the mother and fetus has long enticed immunologists to search for mechanisms of maternal tolerance to fetal antigens. The study of antigen-specific tolerance in murine and human pregnancy has gained new momentum in recent years through the focus on antigen-presenting cells, uterine lymphatics and fetal antigen-specific maternal T cell responses. In mice, we now know that these responses occur within the secondary lymphoid structures as they can be conveniently tracked through the use of defined, often transgenic fetal antigens and maternal T cell receptors. Although the secondary lymphoid organs are sites of both immunization and tolerization to antigens, the immunological processes that occur in response to fetal antigens during the healthy pregnancy must invariably lead to tolerance. The molecular properties of these maternal-fetal tolerogenic interactions are still being unraveled, and are likely to be greatly influenced by tissue-specific microenvironments and the hormonal milieu of pregnancy. In this article, we discuss the events leading to antigen-specific maternal tolerance, including the trafficking of fetal antigens to secondary lymphoid organs, the properties of the antigen-presenting cells that display them to maternal T lymphocytes, and the nature of the ensuing tolerogenic response. Experimental data generated from human biological specimens as well as murine transgenic models are considered.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.