ReviewMolecular neurobiology2009
Ionotropic glutamate receptors in spinal nociceptive processing.
Review in Molecular neurobiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 42 citations in OpenAlex.
- Molecular Anatomy of Synaptic and Extrasynaptic Neurotransmission Between Nociceptive Primary Afferents and Spinal Dorsal Horn Neurons.International journal of molecular sciences · 2025Review
- GluN2A and GluN2B N-Methyl-D-Aspartate Receptor (NMDARs) Subunits: Their Roles and Therapeutic Antagonists in Neurological Diseases.Pharmaceuticals (Basel, Switzerland) · 2023Review
- The Effect of Intrathecal Injection of Dextromethorphan on the Experimental Neuropathic Pain Model.Anesthesiology and pain medicine · 2021Article
- Pathophysiologic Approach to Pain Therapy for Complex Pain Entities: A Narrative Review.Pain and therapy · 2020Review
- Non-canonical heterogeneous cellular distribution and co-localization of CaMKIIα and CaMKIIβ in the spinal superficial dorsal horn.Brain structure & function · 2018Article
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- Glutamatergic Mechanisms Involved in Bladder Overactivity and Pudendal Neuromodulation in Cats.The Journal of pharmacology and experimental therapeutics · 2017Article
- The search for novel analgesics: targets and mechanisms.F1000prime reports · 2015Review
- The development of chronic pain: physiological CHANGE necessitates a multidisciplinary approach to treatment.Current medical research and opinion · 2013Review
- Extracellular microvesicles from astrocytes contain functional glutamate transporters: regulation by protein kinase C and cell activation.Frontiers in cellular neuroscience · 2013Article
- The utility of ionotropic glutamate receptor antagonists in the treatment of nociception induced by epidural glutamate infusion in rats.Surgical neurology international · 2013Article
- Peripheral nerve injury increases glutamate-evoked calcium mobilization in adult spinal cord neurons.Molecular pain · 2012Article
- Brn3a/Pou4f1 regulates dorsal root ganglion sensory neuron specification and axonal projection into the spinal cord.Developmental biology · 2012Article
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- Cellular prion protein protects from inflammatory and neuropathic pain.Molecular pain · 2011Article
- Spinal botulinum neurotoxin B: effects on afferent transmitter release and nociceptive processing.PloS one · 2011Article
- Glutamate receptor phosphorylation and trafficking in pain plasticity in spinal cord dorsal horn.The European journal of neuroscience · 2010Review
- Spinal cord mechanisms of chronic pain and clinical implications.Current pain and headache reports · 2010Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Glutamate is the predominant excitatory transmitter used by primary afferent synapses and intrinsic neurons in the spinal cord dorsal horn. Accordingly, ionotropic glutamate receptors mediate basal spinal transmission of sensory, including nociceptive, information that is relayed to supraspinal centers. However, it has become gradually more evident that these receptors are also crucially involved in short- and long-term plasticity of spinal nociceptive transmission, and that such plasticity have an important role in the pain hypersensitivity that may result from tissue or nerve injury. This review will cover recent findings on pre- and postsynaptic regulation of synaptic function by ionotropic glutamate receptors in the dorsal horn and how such mechanisms contribute to acute and chronic pain.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.