ReviewChild's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery2010
Germinoma in the basal ganglia with an abnormal karyotype: case report and review of the literature.
Review in Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3 citing papers in PubMed, 4 citations in OpenAlex.
- Characteristics of growth disturbances in patients with intracranial germinomas of different origins.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2021Article
- A single-center study of treatment outcomes of pediatric basal ganglia germinoma in Taiwan.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2020Article
- Thalamic germinoma: a challenging diagnosis, case report and literature review.Journal of surgical case reports · 2018Article
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5 authors at 3 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
introductionGerm cell tumor of basal ganglia with abnormal constitutional karyotype has been rarely reported. CASE REPORT: A 9-year-old boy presented with precocious puberty and right hemiparesis. Magnetic resonance imaging showed high intensity on T1-weighted, T2-weighted, and contrast-enhanced T1-weighted images in the left basal ganglia and ipsilateral cerebral hemiatrophy predominantly in the basal ganglia and midbrain. Germinoma in the left basal ganglia was confirmed by stereotactic biopsy and immunochemical examination. His constitutional karyotype was 46, XY, t (8; 19), (p23.1; p13.1), a novel chromosomal abnormality. DISCUSSION: Intracranial germinoma, a potentially curable tumor, should be considered in children with nonspecific neurological symptoms, endocrinologic changes, and ipsilateral cerebral hemiatrophy on computed tomography or magnetic resonance. Investigation of chromosomal aberrations in those patients would clarify the tumorigenesis and lead to possibilities for novel disease-specific therapies.
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