ArticleBulletin of the World Health Organization2009
Zinc and low osmolarity oral rehydration salts for diarrhoea: a renewed call to action.
Article in Bulletin of the World Health Organization, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02601742 (Effectiveness of Oral Rehydration Therapy Supplemented With Zinc in the Management of Diarrhea Acute in Mexican Children), which is not on this map. Cited by 42 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effectiveness of Oral Rehydration Therapy Supplemented With Zinc in the Management of Diarrhea Acute in Mexican Children: Randomized Double-blind Study
Who cites it
42 citing papers in PubMed, 100 citations in OpenAlex.
- Theory-based formative research on oral rehydration salts and zinc use in Lusaka, Zambia.BMC public health · 2016Trial
- A double-blind block randomized clinical trial on the effect of zinc as a treatment for diarrhea in neonatal Holstein calves under natural challenge conditions.Preventive veterinary medicine · 2013Trial
- Strengthening access to zinc and oral rehydration solution for childhood diarrheal treatment in Africa.Global health research and policy · 2025Article
- Prevalence and factors associated with zinc deficiency among preschool-age children in rural districts of Sidama region, Ethiopia: A community-based cross-sectional study.PLOS global public health · 2025Article
- Article
- Antibiotic utilization pattern in treatment of acute diarrheal diseases: the case of Hiwot Fana Specialized University Hospital, Harar, Ethiopia.Journal of pharmaceutical policy and practice · 2023Article
- Nutritional Profiles and Zinc Supplementation among Children with Diarrhea in Bangladesh.The American journal of tropical medicine and hygiene · 2023Article
- Zinc homeostasis and redox alterations in obesity.Frontiers in endocrinology · 2023Review
- The Co-Utilization of Oral Rehydration Solution and Zinc for Treating Diarrhea and Its Associated Factors Among Under-Five Children in Ethiopia: Further Analysis of EDHS 2016.Patient preference and adherence · 2022Article
- The rise and fall of global health issues: an arenas model applied to the COVID-19 pandemic shock.Globalization and health · 2021Article
- A comparative study of the prevalence of zinc deficiency among children with acute diarrhoea in SouthWestern Nigeria.African health sciences · 2020Article
- Increasing coverage of pediatric diarrhea treatment in high-burden countries.Journal of global health · 2019Article
- Progress in the use of ORS and zinc for the treatment of childhood diarrhea.Journal of global health · 2019Article
- Article
- No Clinical Benefit of Empirical Antimicrobial Therapy for Pediatric Diarrhea in a High-Usage, High-Resistance Setting.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2018Observational
- Article
- Assessment of Antibiotic Utilization Pattern in Treatment of Acute Diarrhoea Diseases in Bishoftu General Hospital, Oromia Ethiopia.Advances in medicine · 2018Article
- From guidelines to local realities: evaluation of oral rehydration therapy and zinc supplementation in Guatemala.Revista panamericana de salud publica = Pan American journal of public health · 2017Observational
- Transforming Global Health by Improving the Science of Scale-Up.PLoS biology · 2016Article
- Trends and risk factors for childhood diarrhea in sub-Saharan countries (1990-2013): assessing the neighborhood inequalities.Global health action · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In 2004, WHO and the United Nations Children's Fund (UNICEF) released a joint statement recommending a new lower osmolarity oral rehydration salts (ORS) formulation and zinc supplementation for diarrhoea management. More than 5 years later, diarrhoea remains the second leading cause of death and few children in developing countries are receiving these life-saving interventions. Many countries are stalled in the technicalities of adapting national policy, while others struggle to find the funds for start-up activities. For nearly all countries, zinc supplements for children are not available locally; thus, zinc procurement continues to be a major obstacle. Global resources have not been sufficient to bring diarrhoea management to the forefront; thus, the introduction of these new recommendations has remained slow. Revitalizing diarrhoea management must become an international priority if we are going to reduce the burden of diarrhoea deaths and overall child mortality around the world.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.