ArticlePLoS computational biology2009
Mechanical strength of 17,134 model proteins and cysteine slipknots.
Article in PLoS computational biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 114 citations in OpenAlex.
- ProtAgents: protein discoveryDigital discovery · 2024Article
- MechanoProDB: a web-based database for exploring the mechanical properties of proteins.Database : the journal of biological databases and curation · 2024Article
- Mechanical Behavior of Octopus Egg Tethers Composed of Topologically Constrained, Tandemly Repeated EGF Domains.Biomacromolecules · 2023Article
- The mechanical cell - the role of force dependencies in synchronising protein interaction networks.Journal of cell science · 2022Review
- End-to-End Deep Learning Model to Predict and Design Secondary Structure Content of Structural Proteins.ACS biomaterials science & engineering · 2022Article
- Mapping Mechanostable Pulling Geometries of a Therapeutic Anticalin/CTLA-4 Protein Complex.Nano letters · 2022Article
- Protein folding mechanism revealed by single-molecule force spectroscopy experiments.Biophysics reports · 2021Article
- Viscoelastic properties of wheat gluten in a molecular dynamics study.PLoS computational biology · 2021Article
- Nascent Folding of Proteins Across the Three Domains of Life.Frontiers in molecular biosciences · 2021Article
- Mechanical Unfolding of Proteins-A Comparative Nonequilibrium Molecular Dynamics Study.Biophysical journal · 2020Article
- Structural Characterization of Black Widow Spider Dragline Silk Proteins CRP1 and CRP4.Molecules (Basel, Switzerland) · 2020Article
- Pseudo-Improper-Dihedral Model for Intrinsically Disordered Proteins.Journal of chemical theory and computation · 2020Article
- Dual binding in cohesin-dockerin complexes: the energy landscape and the role of short, terminal segments of the dockerin module.Scientific reports · 2018Article
- Self-assembly of model proteins into virus capsids.Journal of physics. Condensed matter : an Institute of Physics journal · 2017Article
- To Tie or Not to Tie? That Is the Question.Polymers · 2017Review
- Nanomechanical properties of MscL α helices: A steered molecular dynamics study.Channels (Austin, Tex.) · 2017Article
- Topological transformations in proteins: effects of heating and proximity of an interface.Scientific reports · 2017Article
- Unusually high mechanical stability of bacterial adhesin extender domains having calcium clamps.PloS one · 2017Article
- LassoProt: server to analyze biopolymers with lassos.Nucleic acids research · 2016Article
- An Exploration of the Universe of Polyglutamine Structures.PLoS computational biology · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A new theoretical survey of proteins' resistance to constant speed stretching is performed for a set of 17,134 proteins as described by a structure-based model. The proteins selected have no gaps in their structure determination and consist of no more than 250 amino acids. Our previous studies have dealt with 7510 proteins of no more than 150 amino acids. The proteins are ranked according to the strength of the resistance. Most of the predicted top-strength proteins have not yet been studied experimentally. Architectures and folds which are likely to yield large forces are identified. New types of potent force clamps are discovered. They involve disulphide bridges and, in particular, cysteine slipknots. An effective energy parameter of the model is estimated by comparing the theoretical data on characteristic forces to the corresponding experimental values combined with an extrapolation of the theoretical data to the experimental pulling speeds. These studies provide guidance for future experiments on single molecule manipulation and should lead to selection of proteins for applications. A new class of proteins, involving cysteine slipknots, is identified as one that is expected to lead to the strongest force clamps known. This class is characterized through molecular dynamics simulations.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.