ReviewNature reviews. Drug discovery2009
A pre-emptive strike against malaria's stealthy hepatic forms.
Review in Nature reviews. Drug discovery, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
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Who cites it
50 citing papers in PubMed.
- Genome-wide gene expression profiles throughout human malaria parasite liver stage development in humanized mice.Nature microbiology · 2025Article
- Optimization of diastereomeric dihydropyridines as antimalarials.European journal of medicinal chemistry · 2024Article
- Artemisinin-independent inhibitory activity ofLife science alliance · 2022Article
- Chemoprotective antimalarials identified through quantitative high-throughput screening of Plasmodium blood and liver stage parasites.Scientific reports · 2021Article
- Lead Optimization of Second-Generation Acridones as Broad-Spectrum Antimalarials.Journal of medicinal chemistry · 2020Article
- Human unconventional T cells in Plasmodium falciparum infection.Seminars in immunopathology · 2020Review
- The antimalarial screening landscape-looking beyond the asexual blood stage.Current opinion in chemical biology · 2019Review
- TheeLife · 2019Article
- Discovery and Structural Optimization of Acridones as Broad-Spectrum Antimalarials.Journal of medicinal chemistry · 2019Article
- Transcriptomic analysis reveals reduced transcriptional activity in the malaria parasiteeLife · 2018Article
- Recent updates in the discovery and development of novel antimalarial drug candidates.MedChemComm · 2018Review
- A novel immortalized hepatocyte-like cell line (imHC) supports in vitro liver stage development of the human malarial parasite Plasmodium vivax.Malaria journal · 2018Article
- The Plasmodium PI(4)K inhibitor KDU691 selectively inhibits dihydroartemisinin-pretreated Plasmodium falciparum ring-stage parasites.Scientific reports · 2017Article
- Progress in the Optimization of 4(1Chimia · 2017Article
- Towards a Humanized Mouse Model of Liver Stage Malaria Using Ectopic Artificial Livers.Scientific reports · 2017Article
- Current therapies and future possibilities for drug development against liver-stage malaria.The Journal of clinical investigation · 2016Review
- Malaria Parasites: The Great Escape.Frontiers in immunology · 2016Review
- Review
- Plasmodium falciparum full life cycle and Plasmodium ovale liver stages in humanized mice.Nature communications · 2015Article
- Review
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Almost all the drugs that are widely used today against Plasmodium spp., the causative agent of malaria, target the asexual blood stages of the parasite. Widespread drug resistance severely restricts our ability to control malaria and makes it necessary to seek novel antimalarial compounds. Here, we advocate the development of true causal chemoprophylactic drugs that will fully inhibit the obligate short-lived hepatic forms that precede blood infections. Such drugs will prevent pathology and interrupt transmission, and could therefore have an important role in the control of malaria and its eventual eradication.
Indexed as
Identifiers
19876040What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.