ReviewHuman vaccines2010
Egg-independent vaccine strategies for highly pathogenic H5N1 influenza viruses.
Review in Human vaccines, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 52 citations in OpenAlex.
- Optimizing delivery in a multivalent subunit influenza vaccine using mixed polymeric microparticle degradation rates.Journal of controlled release : official journal of the Controlled Release Society · 2025Article
- Post-marketing surveillance study on influenza vaccine in South Korea using a nationwide spontaneous reporting database with multiple data mining methods.Scientific reports · 2022Article
- Development of molecular clamp stabilized hemagglutinin vaccines for Influenza A viruses.NPJ vaccines · 2021Article
- Review
- Development, Biological Characterization, and Immunological Evaluation of Virosome Vaccine against Newcastle Disease in Pakistan.BioMed research international · 2021Article
- Plant-based vaccines and antibodies to combat COVID-19: current status and prospects.Human vaccines & immunotherapeutics · 2020Review
- Quadrivalent cell culture influenza virus vaccine. Comparison to egg-derived vaccine.Human vaccines & immunotherapeutics · 2020Article
- Potential Applications of Plant Biotechnology against SARS-CoV-2.Trends in plant science · 2020Review
- Recombinant Haemagglutinin Derived From the Ciliated ProtozoanFrontiers in immunology · 2019Article
- Universal influenza vaccines: from viruses to nanoparticles.Expert review of vaccines · 2018Review
- Cell culture-derived flu vaccine: Present and future.Human vaccines & immunotherapeutics · 2018Article
- A novel immunization approach for dengue infection based on conserved T cell epitopes formulated in calcium phosphate nanoparticles.Human vaccines & immunotherapeutics · 2017Article
- Egg-Independent Influenza Vaccines and Vaccine Candidates.Vaccines · 2017Review
- Coated protein nanoclusters from influenza H7N9 HA are highly immunogenic and induce robust protective immunity.Nanomedicine : nanotechnology, biology, and medicine · 2017Article
- Review
- Single-dose monomeric HA subunit vaccine generates full protection from influenza challenge.Human vaccines & immunotherapeutics · 2014Article
- Beta-defensin 2 enhances immunogenicity and protection of an adenovirus-based H5N1 influenza vaccine at an early time.Virus research · 2013Article
- Experimental vaccines against potentially pandemic and highly pathogenic avian influenza viruses.Future virology · 2013Article
- Downstream processing of cell culture-derived virus particles.Expert review of vaccines · 2011Review
- Proteomic characterization of influenza H5N1 virus-like particles and their protective immunogenicity.Journal of proteome research · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The emergence of a highly pathogenic H5N1 influenza virus in Hong Kong in 1997 and the subsequent appearance of other H5N1 strains and their spread to several countries in southeast Asia, Africa, the Middle East and Europe has evoked fear of a global influenza pandemic. Vaccines offer the best hope to combat the threat of an influenza pandemic. However, the global demand for a pandemic vaccine cannot be fulfilled by the current egg-based vaccine manufacturing strategies, thus creating a need to explore alternative technologies for vaccine production and delivery. Several egg-independent vaccine approaches such as cell culture-derived whole virus or subvirion vaccines, recombinant protein-based vaccines, virus-like particle (VLP) vaccines, DNA vaccines and viral vector-based vaccines are currently being investigated and appear promising both in preclinical and clinical studies. The present review will highlight the various egg-independent alternative vaccine approaches for pandemic influenza.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.