Evidence map›Paper›PMID 19875832›Full record

ArticleInternational journal of STD & AIDS2009

Indeterminate rapid HIV-1 test results among antenatal and postnatal mothers.

D Matemo, J Kinuthia, F John, M Chung, C Farquhar, G John-Stewart, J Kiarie

Abstract readComparative Study
In one paragraph

Article in International journal of STD & AIDS, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.2field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 12 citations in OpenAlex.

  1. Acceptability and barriers to rapid HIV/syphilis testing among pregnant Wayuu women in Colombia: A cross-sectional pragmatic study.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

D MatemoDepartment of Obstetric and Gynaecology, University of Nairobi, Kenya. daniel.matemo@uonbi.ac.ke
J Kinuthia
F John
M Chung
C Farquhar
G John-Stewart
J Kiarie
University of Nairobi · KEUniversity of Washington · US

Funding

University of Washington/Fred Hutch Center for AIDS ResearchP30AI027757 · NIAID · UNIVERSITY OF WASHINGTON · PI Florian Hladik · 1988 to 2026
$104.9M
INTERNATIONAL TRAINING GRANT IN EPIDEMIOLOGYD43TW000007 · FIC · UNIVERSITY OF WASHINGTON · PI FARQUHAR, CAREY · 1988 to 2012
$16.3M
Pediatric HIV-1 in Africa: Pathogenesis and ManagementK24HD054314 · NICHD · UNIVERSITY OF WASHINGTON · PI JOHN-STEWART, GRACE C. · 2006 to 2016
$1.2M
Protective Immune Responses in HIV-1 Exposed InfantsK23HD041879 · NICHD · UNIVERSITY OF WASHINGTON · PI FARQUHAR, CAREY · 2002 to 2006
$628k
Widow inheritance and HIV infection in KenyaR01TW006230 · FIC · UNIVERSITY OF NAIROBI · PI AGOT, KAWANGO · 2002 to 2006
$313k
Interventions to reduce HIV-1 incidence after deliveryR01TW006640 · FIC · UNIVERSITY OF NAIROBI · PI KIARIE, JAMES NJOGU · 2003 to 2006
$182k
SPECIAL INTERNATIONAL POSTDOCTORAL RESEARCH PROGRAMT22TW000001 · FIC · UNIVERSITY OF WASHINGTON · PI KREISS, JOAN K · 1988 to 1999
–
FIC NIH HHS D43 TW000007FIC NIH HHS D43 TW06230FIC NIH HHS R01 TW006230FIC NIH HHS R01 TW006640FIC NIH HHS R01 TW006640-01FIC NIH HHS T22 TW000001FIC NIH HHS T22-TW00001NIAID NIH HHS P30 AI027757NICHD NIH HHS K23 HD041879NICHD NIH HHS K24 HD054314
6 · The paper itself

Abstract

The sensitivity and specificity of rapid HIV-1 tests may be altered during pregnancy and postpartum. We conducted a study to determine the prevalence and correlates of false-positive Abbott Determine and false-negative Uni-Gold rapid HIV-1 test results among antenatal and postnatal mothers attending a primary care clinic in Nairobi, Kenya. Mothers were tested for HIV-1 using Abbott Determine and non-reactive results were considered HIV-1 antibody negative. Reactive samples by Determine were re-tested by Uni-Gold. Vironostika HIV-1 and Uni-FORM II Enzyme-linked immunosorbent assays were used to confirm samples that had positive Abbott Determine and negative Uni-Gold. Among 2311 women who accepted HIV-1 testing, 1238 (54%) were tested antenatally and 1073 (46%) were tested postnatally. Of tested women, 274 (12%) women were reactive by Abbott Determine and on retesting with Uni-Gold 30 (11%) had indeterminate results. The prevalence of indeterminate results was significantly higher in antenatal women than in postnatal women (2% versus 1%, P = 0.03). In conclusion, indeterminate rapid HIV-1 test results are more common in the antenatal period and appropriate safeguards to confirm HIV-1 infection status should be implemented in antenatal programmes.

Indexed as

False Negative ReactionsFalse Positive ReactionsFemaleHIV-1HIV InfectionsHumansPregnancyPregnancy Complications, InfectiousReagent Kits, DiagnosticSensitivity and SpecificityReagent Kits, Diagnostic

Identifiers

PMID19875832
PMCPMC3223243
OpenAlexW1994407118

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.