ArticleJournal of the American Society of Nephrology : JASN2009
25-hydroxyvitamin D levels, race, and the progression of kidney disease.
Article in Journal of the American Society of Nephrology : JASN, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 76 papers.
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Who cites it
76 citing papers in PubMed.
- Adjunctive Active Vitamin D Decreases Kidney Function during Treatment of Secondary Hyperparathyroidism with Extended-Release Calcifediol in Non-Dialysis Chronic Kidney Disease in a Randomized Trial.American journal of nephrology · 2025Trial
- The effects of omega-3 fatty acid on vitamin D activation in hemodialysis patients: a pilot study.Marine drugs · 2015Trial
- Associations of plasma 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D concentrations with death and progression to maintenance dialysis in patients with advanced kidney disease.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2012Trial
- Oral supplementation with cholecalciferol 800 IU ameliorates albuminuria in Chinese type 2 diabetic patients with nephropathy.PloS one · 2012Trial
- Serum 25-hydroxyvitamin D concentration is associated with functional capacity in older adults with heart failure.American heart journal · 2010Trial
- Current Controversies on Adequate Circulating Vitamin D Levels in CKD.International journal of molecular sciences · 2025Review
- Vitamin D Deficiency, Chronic Kidney Disease and Periodontitis.Medicina (Kaunas, Lithuania) · 2024Review
- Association of serum 25-hydroxyvitamin D with cardiovascular and all-cause mortality in patients with chronic kidney disease: NHANES 2007‒2018 results.Clinics (Sao Paulo, Brazil) · 2024Article
- The correlation of metabolic and renal biomarkers with vitamin D status in postmenopausal women.Journal of medical biochemistry · 2023Article
- The association between vitamin D deficiency and risk of renal event: Results from the Korean cohort study for outcomes in patients with chronic kidney disease (KNOW-CKD).Frontiers in medicine · 2023Article
- Hypovitaminosis D Is Prevalent in Patients With Renal AL Amyloidosis and Associated With Renal Outcome.Frontiers in endocrinology · 2022Article
- Association of Serum 25 (OH) Vitamin D With Chronic Kidney Disease Progression in Type 2 Diabetes.Frontiers in endocrinology · 2022Article
- Recommendations on the measurement and the clinical use of vitamin D metabolites and vitamin D binding protein - A position paper from the IFCC Committee on bone metabolism.Clinica chimica acta; international journal of clinical chemistry · 2021Review
- Role of vitamin D in the pathogenesis of atheromatosis.Nutrition, metabolism, and cardiovascular diseases : NMCD · 2021Article
- Non-classical Vitamin D Actions for Renal Protection.Frontiers in medicine · 2021Review
- FGF23: A Review of Its Role in Mineral Metabolism and Renal and Cardiovascular Disease.Disease markers · 2021Review
- Free 25-hydroxyvitamin-D concentrations are lower in children with renal transplant compared with chronic kidney disease.Pediatric nephrology (Berlin, Germany) · 2020Article
- Association of Vitamin D with the TaqI Polymorphism of the VDR Gene in Older Women Attending the Basic Health Unit of the Federal District, DF (Brazil).Journal of aging research · 2020Article
- Daily ambient temperature is associated with biomarkers of kidney injury in older Americans.Environmental research · 2019Article
- Vitamin D deficiency and kidney hyperfiltration: a mechanism of kidney injury?Annals of translational medicine · 2019Article
16 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Black individuals have lower 25-hydroxyvitamin D [25(OH)D] levels and experience a disproportionate burden of ESRD compared with white individuals. Animal studies suggest that vitamin D has renoprotective effects. We evaluated the contribution of low 25(OH)D levels on incidence of ESRD using data from the Third National Health and Nutrition Examination Survey-linked Medicare claims files (n = 13,328). We included baseline (1988 through 1994) measurements of 25(OH)D and assessed the incidence of ESRD through July 31, 2001. Overall, 34% of non-Hispanic black individuals had 25(OH)D levels <15 ng/ml compared with 5% of non-Hispanic white individuals (P < 0.001). During a median of 9.1 yr, 65 participants developed ESRD. After adjustment for demographic, socioeconomic, and clinical and laboratory factors (including diabetes, hypertension, estimated GFR, and albuminuria), participants with 25(OH)D levels <15 ng/ml had a 2.6-fold greater incidence of ESRD than those with levels > or =15 ng/ml (incidence rate ratio 2.64; 95% confidence interval [CI] 1.00 to 7.05; P = 0.05). After adjustment for clinical covariates but not 25(OH)D levels, non-Hispanic black individuals had a 2.83-fold (95% CI 1.03 to 7.77) higher risk for developing ESRD compared with non-Hispanic white individuals. Additional adjustment for 25(OH)D levels reduced the risk by 58% (incidence rate ratio 1.77; 95% CI 0.38 to 8.21). In summary, low 25(OH)D levels associate with development of ESRD even after adjustment for multiple risk factors. Low 25(OH)D levels may account for a substantial proportion of the increased risk for ESRD experienced by black individuals.
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