ArticleInvestigative ophthalmology & visual science2010
Episcleral venous pressure responses to topical nitroprusside and N-Nitro-L-arginine methyl ester.
Article in Investigative ophthalmology & visual science, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 28 citations in OpenAlex.
- Assessing Agreement of Intraocular Pressure from Four Mechanistically Different Tonometers in the Eye Dynamics and Engineering Network Clinical Trial.Ophthalmology. GlaucomaTrial
- Relationship Between Diurnal Variations of Episcleral Venous Pressure and Intraocular Pressure.Investigative ophthalmology & visual science · 2025Article
- Effect of Topical Phenylephrine 2.5% on Episcleral Venous Pressure in Normal Human Eyes.Investigative ophthalmology & visual science · 2021Article
- NCX 667, a Novel Nitric Oxide Donor, Lowers Intraocular Pressure in Rabbits, Dogs, and Non-Human Primates and Enhances TGFβ2-Induced Outflow in HTM/HSC Constructs.Investigative ophthalmology & visual science · 2021Article
- Episcleral Venous Pressure and the Ocular Hypotensive Effects of Topical and Intracameral Prostaglandin Analogs.Journal of glaucoma · 2019Review
- Localized and Controlled Delivery of Nitric Oxide to the Conventional Outflow Pathway via Enzyme Biocatalysis: Toward Therapy for Glaucoma.Advanced materials (Deerfield Beach, Fla.) · 2017Article
- Critical evaluation of latanoprostene bunod in the treatment of glaucoma.Clinical ophthalmology (Auckland, N.Z.) · 2016Review
- Role of nitric oxide in murine conventional outflow physiology.American journal of physiology. Cell physiology · 2015Article
- Effect of AR-13324 on episcleral venous pressure in Dutch belted rabbits.Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics · 2015Article
- Episcleral venous pressure and IOP responses to central electrical stimulation in the rat.Investigative ophthalmology & visual science · 2013Article
- Effect of nitric oxide on anterior segment physiology in monkeys.Investigative ophthalmology & visual science · 2013Article
- Effects of head down tilt on episcleral venous pressure in a rabbit model.Experimental eye research · 2013Article
- Effect of nitric oxide compounds on monkey ciliary muscle in vitro.Experimental eye research · 2011Article
- Ciliary blood flow and aqueous humor production.Progress in retinal and eye research · 2011Article
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
purposeTo determine the episcleral venous pressure (EVP) responses to nitroprusside (NP) and L-NAME.
methodsIn anesthetized rabbits (n = 36), arterial pressure and IOP were measured by direct cannulation, and carotid blood flow and heart rate were measured with an ultrasound flowmeter and cardiotachometer. EVP was measured in two groups with a servonull system. Group 1 (n = 13) was given NP (50 microL, 10 mg/mL). Group 2 (n = 10) was given L-NAME (100 microL, 10 mg/mL) followed by NP (50 microL, 10 mg/mL). In group 3 (n = 13), fluorophotometric aqueous flow was measured before and after NP (100 microL, 10 mg/mL).
resultsSystemic parameters were unaffected by treatment in all groups. In group 1, NP increased EVP from 9.1 +/- 0.6 to 11.6 +/- 0.8 mm Hg (P < 0.01) and IOP from 18.7 +/- 1.4 to 23.9 +/- 1.6 mm Hg (P < 0.01). In group 2, L-NAME lowered EVP from 11.5 +/- 1.2 to 8.8 +/- 1.0 mm Hg (P < 0.01) and subsequent NP increased EVP to 13.9 +/- 1.7 mm Hg (P < 0.01 versus L-NAME and baseline). L-NAME decreased IOP from 20.8 +/- 1.7 to 16.7 +/- 1.8 mm Hg (P < 0.01), and then it increased to 20.7 +/- 1.3 mm Hg after NP (P < 0.01 versus L-NAME and P > 0.05 versus baseline). In group 3, NP increased IOP from 16.6 +/- 0.7 to 20.0 +/- 0.9 mm Hg (P < 0.01) but did not alter aqueous flow (2.65 +/- 0.3 vs. 3.0 +/- 0.3 microL/min, P > 0.05).
conclusionsBecause a topical NO donor raises EVP and a topical NO synthase inhibitor lowers EVP, the authors conclude that EVP is modulated by NO.
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