Trial reportPsychosomatic medicine2009
Overload: impact of incident stressful events on antiretroviral medication adherence and virologic failure in a longitudinal, multisite human immunodeficiency virus cohort study.
Trial report in Psychosomatic medicine, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03848858 (The Efficacy of Eye Movement Desensitization and Reprocessing Therapy Versus Treatment-As-Usual in a Pilot Randomized Controlled Trial in Reducing Clinical Symptoms and Biological Markers of HIV in Patients With a Recent Diagnosis of HIV), which is not on this map. Cited by 77 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Efficacy of Eye Movement Desensitization and Reprocessing Therapy Versus Treatment-As-Usual in a Pilot Randomized Controlled Trial in Reducing Clinical Symptoms and Biological Markers of HIV in Patients With a Recent Diagnosis of HIV
Who cites it
77 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Safer disclosure of HIV serostatus for women living with HIV who experience or fear violence: a systematic review.Journal of the International AIDS Society · 2015Pooled it
- Home foreclosure, health, and mental health: a systematic review of individual, aggregate, and contextual associations.PloS one · 2015Pooled it
- Predictors and correlates of adherence to combination antiretroviral therapy (ART) for chronic HIV infection: a meta-analysis.BMC medicine · 2014Pooled it
- Sex differences in HIV outcomes in the highly active antiretroviral therapy era: a systematic review.AIDS research and human retroviruses · 2014Pooled it
- Trial
- Mechanisms of quality-of-life improvement in treatment for alcohol use disorder.Journal of consulting and clinical psychology · 2022Trial
- Ongoing life stressors and suicidal ideation among HIV-infected adults with depression.Journal of affective disorders · 2016Trial
- Differentiating Exposure From Consequence: A Longitudinal Examination of Trauma and Posttraumatic Distress in a Public HIV Care Clinic.AIDS and behavior · 2026Article
- From trait emotional intelligence to wellbeing and growth: the role of adaptive coping during hardship.Frontiers in psychology · 2026Article
- Coping strategies in challenging situations among informal caregivers: validation of the newly developed six-item German short version of the Brief COPE Inventory (COPE 6).BMC psychology · 2025Article
- Optimizing an App-Based Just-in-Time Adaptive Intervention for Stimulant Use Among Sexual Minority Men Living with HIV: Protocol for a Community-Engaged Research Approach and Hybrid-Experimental Design.JMIR research protocols · 2025Article
- Article
- Sexual Minority Men Living with HIV's Interest in Yoga vs. MBSR as an Adjunct to an App-Based Positive Affect Intervention: A Focus Group Study.Current research in complementary & alternative medicine · 2025Article
- Article
- HIV status affects PTSD symptom severity, psychophysiology, and heart rate variability in women with low but not high exposure to childhood maltreatment.Stress (Amsterdam, Netherlands) · 2024Article
- HIV Interacts with Posttraumatic Stress Disorder to Impact Fear Psychophysiology in Trauma-Exposed Black Women.Women's health reports (New Rochelle, N.Y.) · 2024Article
- Adverse childhood experiences, mental illness, HIV and offending among female inmates in Durban, South Africa.The South African journal of psychiatry : SAJP : the journal of the Society of Psychiatrists of South Africa · 2024Article
- A Trauma-Informed, Geospatially Aware, Just-in-Time Adaptive mHealth Intervention to Support Effective Coping Skills Among People Living With HIV in New Orleans: Development and Protocol for a Pilot Randomized Controlled Trial.JMIR research protocols · 2023Article
- Predicting salivary cortisol and sexual behavior stigma among MSM in the American Men's Internet Survey 2019.Scientific reports · 2023Article
- Article
17 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
objectiveTo examine the influence of incident stressful experiences on antiretroviral medication adherence and treatment outcomes. Past trauma history predicts poorer medication adherence and health outcomes. Human immunodeficiency virus (HIV)-infected individuals experience frequently traumatic and stressful events, such as sexual and physical assault, housing instability, and major financial, employment, and legal difficulties.
methodsWe measured prospectively incident stressful and traumatic events, medication adherence, and viral load over 27 months in an eight-site, five-state study. Using multivariable logistic and generalized estimating equation modeling, we assessed the impact of incident stressful events on 27-month changes in self-reported medication adherence and virologic failure (viral load = >or=400 c/mL).
resultsOf 474 participants on antiretroviral therapy at baseline, 289 persons were interviewed and still received treatment at 27 months. Participants experiencing the median number of incident stressful events (n = 9) had over twice the predicted odds (odds ratio = 2.32) of antiretroviral medication nonadherence at follow-up compared with those with no events. Stressful events also predicted increased odds of virologic failure during follow-up (odds ratio = 1.09 per event).
conclusionsIncident stressful events are exceedingly common in the lives of HIV-infected individuals and negatively affect antiretroviral medication adherence and treatment outcomes. Interventions to address stress and trauma are needed to improve HIV outcomes.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.