ArticleDiabetes2010
Maternal age at birth and childhood type 1 diabetes: a pooled analysis of 30 observational studies.
Article in Diabetes, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.
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Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it, 94 citations in OpenAlex.
- Overweight and obesity in youth with type 1 diabetes.Annual review of nursing research · 2013Pooled it
- Increasing incidence of type 1 diabetes in children and adolescents from 2012 to 2021 in Germany: trends before and during the COVID-19 pandemic.European journal of epidemiology · 2026Article
- Parental age and its influence on functional dependency and cognitive decline in older adults: a cohort analysis.Journal of health, population, and nutrition · 2026Article
- Stable heritability of type 1 diabetes in a Swedish Nationwide Cohort Study.Nature communications · 2025Article
- Epidemiology and temporal trends of childhood type 1 diabetes in China: an analysis of the GBD 2021.Frontiers in endocrinology · 2025Article
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- National and sub-national burden and trend of type 1 diabetes in 31 provinces of Iran, 1990-2019.Scientific reports · 2023Article
- Extremely Early Appearance of Islet Autoantibodies in Genetically Susceptible Children.Pediatric diabetes · 2023Observational
- Serum parabens and its correlations with immunologic and cellular markers in Southern Taiwan industrialized city systemic lupus erythematosus patients.Journal of the Chinese Medical Association : JCMA · 2022Article
- Maternal diabetes negatively impacts fetal health.Open biology · 2022Review
- Birth Order, Caesarean Section, or Daycare Attendance in Relation to Child- and Adult-Onset Type 1 Diabetes: Results from the German National Cohort.International journal of environmental research and public health · 2022Article
- Prediction of Type 1 Diabetes at Birth: Cord Blood Metabolites vs Genetic Risk Score in the Norwegian Mother, Father, and Child Cohort.The Journal of clinical endocrinology and metabolism · 2021Article
- Seasonal variation and epidemiological parameters in children from Greece with type 1 diabetes mellitus (T1DM).Pediatric research · 2021Article
- Stress Hyperglycemia in Children and Adolescents as a Prognostic Indicator for the Development of Type 1 Diabetes Mellitus.Frontiers in pediatrics · 2021Review
- Excessive Gestational Weight Gain: Long-Term Consequences for the Child.Journal of clinical medicine · 2020Article
- Type 1 diabetes-early life origins and changing epidemiology.The lancet. Diabetes & endocrinology · 2020Review
- Association between maternal age and outcomes in Kawasaki disease patients.Pediatric rheumatology online journal · 2019Article
- Perinatal risk factors for type 1 diabetes revisited: a population-based register study.Diabetologia · 2019Article
- Persistent epigenetic changes in adult daughters of older mothers.Epigenetics · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
28 authors at 20 institutions in 15 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe aim if the study was to investigate whether children born to older mothers have an increased risk of type 1 diabetes by performing a pooled analysis of previous studies using individual patient data to adjust for recognized confounders. RESEARCH DESIGN AND
methodsRelevant studies published before June 2009 were identified from MEDLINE, Web of Science, and EMBASE. Authors of studies were contacted and asked to provide individual patient data or conduct prespecified analyses. Risk estimates of type 1 diabetes by maternal age were calculated for each study, before and after adjustment for potential confounders. Meta-analysis techniques were used to derive combined odds ratios and to investigate heterogeneity among studies.
resultsData were available for 5 cohort and 25 case-control studies, including 14,724 cases of type 1 diabetes. Overall, there was, on average, a 5% (95% CI 2-9) increase in childhood type 1 diabetes odds per 5-year increase in maternal age (P = 0.006), but there was heterogeneity among studies (heterogeneity I(2) = 70%). In studies with a low risk of bias, there was a more marked increase in diabetes odds of 10% per 5-year increase in maternal age. Adjustments for potential confounders little altered these estimates.
conclusionsThere was evidence of a weak but significant linear increase in the risk of childhood type 1 diabetes across the range of maternal ages, but the magnitude of association varied between studies. A very small percentage of the increase in the incidence of childhood type 1 diabetes in recent years could be explained by increases in maternal age.
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Registered trials
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