ArticleMicrobiology (Reading, England)2010
The inositol regulon controls viability in Candida glabrata.
Article in Microbiology (Reading, England), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 26 citations in OpenAlex.
- Population genomic analyses reveal high diversity, recombination and nosocomial transmission amongMicrobial genomics · 2024Article
- The Effectiveness of Voriconazole in Therapy of Candida glabrata's Biofilms Oral Infections and Its Influence on the Matrix Composition and Gene Expression.Mycopathologia · 2017Article
- Differential Proteome Analysis of a Flor Yeast Strain under Biofilm Formation.International journal of molecular sciences · 2017Article
- Candida albicans OPI1 regulates filamentous growth and virulence in vaginal infections, but not inositol biosynthesis.PloS one · 2015Article
- Candida glabrata: a review of its features and resistance.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2014Review
- Cryptococcus and beyond--inositol utilization and its implications for the emergence of fungal virulence.PLoS pathogens · 2012Article
- Differential phytate utilization in Candida species.Mycopathologia · 2011Article
- Loss of mitochondrial functions associated with azole resistance in Candida glabrata results in enhanced virulence in mice.Antimicrobial agents and chemotherapy · 2011Article
- Two major inositol transporters and their role in cryptococcal virulence.Eukaryotic cell · 2011Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Inositol is essential in eukaryotes, and must be imported or synthesized. Inositol biosynthesis in Saccharomyces cerevisiae is controlled by three non-essential genes that make up the inositol regulon: ScINO2 and ScINO4, which together encode a heterodimeric transcriptional activator, and ScOPI1, which encodes a transcriptional repressor. ScOpi1p inhibits the ScIno2-ScIno4p activator in response to extracellular inositol levels. An important gene controlled by the inositol regulon is ScINO1, which encodes inositol-3-phosphate synthase, a key enzyme in inositol biosynthesis. In the pathogenic yeast Candida albicans, homologues of the S. cerevisiae inositol regulon genes are 'transcriptionally rewired'. Instead of regulating the CaINO1 gene, CaINO2 and CaINO4 regulate ribosomal genes. Another Candida species that is a prevalent cause of infections is Candida glabrata; however, C. glabrata is phylogenetically more closely related to S. cerevisiae than C. albicans. Experiments were designed to determine if C. glabrata homologues of the inositol regulon genes function similarly to S. cerevisiae or are transcriptionally rewired. CgINO2, CgINO4 and CgOPI1 regulate CgINO1 in a manner similar to that observed in S. cerevisiae. However, unlike in S. cerevisiae, CgOPI1 is essential. Genetic data indicate that CgOPI1 is a repressor that affects viability by regulating activation of a target of the inositol regulon.
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