Evidence map›Paper›PMID 19875426›Full record

Trial reportBMJ (Clinical research ed.)2009

Effect of tailored practice and patient care plans on secondary prevention of heart disease in general practice: cluster randomised controlled trial.

A W Murphy, M E Cupples, S M Smith, M Byrne, M C Byrne, J Newell, SPHERE study team

Registry-linked trialAbstract readMulticenter StudyRandomized Controlled Trial
In one paragraph

Trial report in BMJ (Clinical research ed.), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01826929 (Effectiveness of a New Health Care Organization Model in Primary Care for Chronic Cardiovascular Disease Patients Based on a Multifactorial Intervention), which is not on this map. Cited by 43 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed, 11 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01826929 naunknown statusnot on this mapstarted 2013, after this paper: background citation

Effectiveness of a New Health Care Organization Model in Primary Care for Chronic Cardiovascular Disease Patients Based on a Multifactorial Intervention: The PROPRESE Randomized Controlled Trial.

TypeinterventionalSponsorFundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat ValencianaRan2013Enrolled300ConditionsIschemic Heart DiseaseArmsTherapeutic education
3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 11 syntheses or guidelines pooled it.

  1. Tailored interventions to address determinants of practice.The Cochrane database of systematic reviews · 2026
    Pooled it
  2. Pooled it
  3. Pooled it
  4. Behaviour change techniques in personalised care planning for older people: a systematic review.The British journal of general practice : the journal of the Royal College of General Practitioners · 2021
    Pooled it
  5. Pooled it
  6. Guideline
  7. Pooled it
  8. Primary care organisational interventions for secondary prevention of ischaemic heart disease: a systematic review and meta-analysis.The British journal of general practice : the journal of the Royal College of General Practitioners · 2015
    Pooled it
  9. Guideline
  10. Tailored interventions to address determinants of practice.The Cochrane database of systematic reviews · 2015
    Pooled it
  11. Pooled it
  12. CPAP increases physical activity in obstructive sleep apnea with cardiovascular disease.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2021
    Trial
  13. Long-term cost effectiveness of cardiac secondary prevention in primary care in the Republic of Ireland and Northern Ireland.The European journal of health economics : HEPAC : health economics in prevention and care · 2017
    Trial
  14. Trial
  15. Trial
  16. Trial
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  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

A W MurphyDepartment of General Practice, National University of Ireland Galway, Ireland. andrew.murphy@nuigalway.ie
M E Cupples
S M Smith
M Byrne
M C Byrne
J Newell
SPHERE study team

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo test the effectiveness of a complex intervention designed, within a theoretical framework, to improve outcomes for patients with coronary heart disease.

designCluster randomised controlled multicentre trial.

settingGeneral practices in Northern Ireland and the Republic of Ireland, regions with different healthcare systems.

participants903 patients with established coronary heart disease registered with one of 48 practices.

interventionTailored care plans for practices (practice based training in prescribing and behaviour change, administrative support, quarterly newsletter), and tailored care plans for patients (motivational interviewing, goal identification, and target setting for lifestyle change) with reviews every four months at the practices. Control practices provided usual care.

main outcome measuresThe proportion of patients at 18 month follow-up above target levels for blood pressure and total cholesterol concentration, and those admitted to hospital, and changes in physical and mental health status (SF-12).

resultsAt baseline the numbers (proportions) of patients above the recommended limits were: systolic blood pressure greater than 140 mm Hg (305/899; 33.9%, 95% confidence interval 30.8% to 33.9%), diastolic blood pressure greater than 90 mm Hg (111/901; 12.3%, 10.2% to 14.5%), and total cholesterol concentration greater than 5 mmol/l (188/860; 20.8%, 19.1% to 24.6%). At the 18 month follow-up there were no significant differences between intervention and control groups in the numbers (proportions) of patients above the recommended limits: systolic blood pressure, intervention 98/360 (27.2%) v control, 133/405 (32.8%), odds ratio 1.51 (95% confidence interval 0.99 to 2.30; P=0.06); diastolic blood pressure, intervention 32/360 (8.9%) v control, 40/405 (9.9%), 1.40 (0.75 to 2.64; P=0.29); and total cholesterol concentration, intervention 52/342 (15.2%) v control, 64/391 (16.4%), 1.13 (0.63 to 2.03; P=0.65). The number of patients admitted to hospital over the 18 month study period significantly decreased in the intervention group compared with the control group: 107/415 (25.8%) v 148/435 (34.0%), 1.56 (1.53 to 2.60; P=0.03).

conclusionsAdmissions to hospital were significantly reduced after an intensive 18 month intervention to improve outcomes for patients with coronary heart disease, but no other clinical benefits were shown, possibly because of a ceiling effect related to improved management of the disease.

trial registrationCurrent Controlled Trials ISRCTN24081411.

Indexed as

AgedBlood PressureCholesterolCoronary DiseaseFamily PracticeFemaleHealth StatusHospitalizationHumansHypercholesterolemiaHypertensionIrelandLife StyleMaleMental HealthNorthern IrelandCholesterol

Identifiers

PMID19875426
PMCPMC2770592

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.