ArticleChemistry & biology2009
Hemoglobin digestion in blood-feeding ticks: mapping a multipeptidase pathway by functional proteomics.
Article in Chemistry & biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 85 papers.
What it found
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Who cites it
85 citing papers in PubMed, 201 citations in OpenAlex.
- RNAi-mediated knockdown of the poultry red mite cathepsin D-1 impacts haemoglobin digestion.Parasites & vectors · 2026Article
- An insight into the ovary and midgut transcriptome of Dermacentor nitens tick.Ticks and tick-borne diseases · 2026Article
- FirstCurrent research in parasitology & vector-borne diseases · 2026Article
- Exploring Spiders Without Venom as New Sources of Peptidase Inhibitors.International journal of molecular sciences · 2025Article
- Feeding on different hosts displays different hemolymph protein compositions in Haemaphysalis qinghaiensis tick.Experimental & applied acarology · 2025Article
- Egg Protein Compositions over Embryonic Development inAnimals : an open access journal from MDPI · 2024Article
- A multi-omics approach for understanding blood digestion dynamics in Ixodes scapularis and identification of anti-tick vaccine targets.Ticks and tick-borne diseases · 2024Article
- Exploring the longitudinal expression dynamics of midguts in adult female Amblyomma americanum ticks.BMC genomics · 2024Article
- Exploring midgut expression dynamics: longitudinal transcriptomic analysis of adult femalebioRxiv : the preprint server for biology · 2024Article
- Nature-Inspired Gallinamides Are Potent Antischistosomal Agents: Inhibition of the Cathepsin B1 Protease Target and Binding Mode Analysis.ACS infectious diseases · 2024Article
- Effect of ivermectin, amitraz and fipronil on midgut epithelium and digestive enzyme profile in Rhipicephalus microplus ticks (Acari: Ixodidae).Experimental & applied acarology · 2024Article
- A longitudinal transcriptomic analysis of Rhipicephalus microplus midgut upon feeding.Ticks and tick-borne diseases · 2024Article
- Histopathological effects of the fruit extract of Citrullus colocynthis on the ovary of the tick Hyalomma dromedarii.Experimental & applied acarology · 2024Article
- Changes in saliva protein profile throughout Rhipicephalus microplus blood feeding.Parasites & vectors · 2024Article
- Insight Into the Dynamics of the Ixodes ricinus Nymphal Midgut Proteome.Molecular & cellular proteomics : MCP · 2023Article
- Characterization of the complete mitochondrial genomes of five hard ticks and phylogenetic implications.Parasitology research · 2023Article
- A longitudinal transcriptomic analysis from unfed to post-engorgement midguts of adult female Ixodes scapularis.Scientific reports · 2023Review
- Blood-feeding adaptations and virome assessment of the poultry red mite Dermanyssus gallinae guided by RNA-seq.Communications biology · 2023Article
- Mapping structural variations iniScience · 2023Article
- A draft of the genome of the Gulf Coast tick, Amblyomma maculatum.Ticks and tick-borne diseases · 2023Article
25 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 5 institutions in 3 countries.
Funding
Abstract
Hemoglobin digestion is an essential process for blood-feeding parasites. Using chemical tools, we deconvoluted the intracellular hemoglobinolytic cascade in the tick Ixodes ricinus, a vector of Lyme disease and tick-borne encephalitis. In tick gut tissue, a network of peptidases was demonstrated through imaging with specific activity-based probes and activity profiling with peptidic substrates and inhibitors. This peptidase network is induced upon blood feeding and degrades hemoglobin at acidic pH. Selective inhibitors were applied to dissect the roles of the individual peptidases and to determine the peptidase-specific cleavage map of the hemoglobin molecule. The degradation pathway is initiated by endopeptidases of aspartic and cysteine class (cathepsin D supported by cathepsin L and legumain) and is continued by cysteine amino- and carboxy-dipeptidases (cathepsins C and B). The identified enzymes are potential targets to developing novel anti-tick vaccines.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.