ArticleInternational journal for parasitology2010
Inactivation of the complement anaphylatoxin C5a by secreted products of parasitic nematodes.
Article in International journal for parasitology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 26 citations in OpenAlex.
- Enigmatic Roles of Complement Anaphylatoxin Signaling in Health and Disease.Immune network · 2025Review
- Serine protease RAYM_01812 (SspA) inhibits complement-mediated killing and monocyte chemotaxis and contributes to virulence ofVirulence · 2024Article
- IgG4 antibodies from patients with asymptomatic bancroftian filariasis inhibit the binding of IgG1 and IgG2 to C1q in a Fc-Fc-dependent mechanism.Parasitology research · 2019Article
- The liver proteome in a mouse model for Ascaris suum resistance and susceptibility: evidence for an altered innate immune response.Parasites & vectors · 2019Article
- Preventive and therapeutic effects of Trichinella spiralis adult extracts on allergic inflammation in an experimental asthma mouse model.Parasites & vectors · 2019Article
- A core set of venom proteins is released by entomopathogenic nematodes in the genus Steinernema.PLoS pathogens · 2019Article
- Cloning and characterization of the first serine carboxypeptidase from a plant parasitic nematode, Radopholus similis.Scientific reports · 2017Article
- A Proteomic Investigation of Hepatic Resistance to Ascaris in a Murine Model.PLoS neglected tropical diseases · 2016Article
- Serine proteases of parasitic helminths.The Korean journal of parasitology · 2015Review
- Complement and HIV-I infection/HIV-associated neurocognitive disorders.Journal of neurovirology · 2014Review
- Live Brugia malayi microfilariae inhibit transendothelial migration of neutrophils and monocytes.PLoS neglected tropical diseases · 2012Article
- RNAi-mediated silencing of paramyosin expression in Trichinella spiralis results in impaired viability of the parasite.PloS one · 2012Article
- Heightened measures of immune complex and complement function and immune complex-mediated granulocyte activation in human lymphatic filariasis.The American journal of tropical medicine and hygiene · 2011Article
- Trichinella spiralis paramyosin binds to C8 and C9 and protects the tissue-dwelling nematode from being attacked by host complement.PLoS neglected tropical diseases · 2011Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Given the importance of the complement anaphylatoxins in cellular recruitment during infection, the ability of secreted products from larval stages of Brugia malayi and Trichinella spiralis to influence C5a-mediated chemotaxis of human peripheral blood granulocytes in vitro was examined. Secreted products from B. malayi microfilariae almost completely abolished chemotaxis. This inhibition was blocked by phenylmethylsulphonyl fluoride, indicating the presence of a serine protease, which was subsequently shown to cleave C5a. In contrast, secreted products from T. spiralis infective larvae showed modest inhibition of C5a-mediated granulocyte chemotaxis, and this was blocked by potato carboxypeptidase inhibitor, an inhibitor of several metallocarboxypeptidases. Adult and larval stages of both parasites were demonstrated to secrete carboxypeptidases which cleaved hippuryl-L-lysine and hippuryl-L-arginine, and the T. spiralis enzyme was partially characterised. The data are discussed with reference to inflammation in parasitic nematode infection.
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