ArticleCritical care (London, England)2009
Incidence of propofol-related infusion syndrome in critically ill adults: a prospective, multicenter study.
Article in Critical care (London, England), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers.
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Who cites it
70 citing papers in PubMed, 208 citations in OpenAlex.
- Volatile versus propofol sedation after cardiac valve surgery: a single-center prospective randomized controlled trial.Critical care (London, England) · 2024Trial
- Septic shock with no diagnosis at 24 hours: a pragmatic multicenter prospective cohort study.Critical care (London, England) · 2016Trial
- Perioperative Continuous Propofol Infusion in the Pediatric Cardiac Intensive Care Unit: A 25-Year Retrospective Study.Pediatric cardiology · 2026Article
- Advantages of Remimazolam in Pediatric Anesthesia: A Narrative Review.Children (Basel, Switzerland) · 2026Review
- Article
- Volatile anesthetics in the intensive care unit.Anaesthesiology intensive therapy · 2025Review
- Propofol-related infusion syndrome happened in a non-critically ill perioperative young patient: A case report.SAGE open medical case reports · 2025Article
- Propofol-related biological alterations and incidence of propofol infusion syndrome in status epilepticus: a 10-year cohort study.Frontiers in neurology · 2025Article
- The safety of high dose continuous propofol infusion in the pediatric intensive care unit at an academic medical center.Frontiers in pediatrics · 2025Article
- Risk of medication-induced lactic acidosis and hyperlactatemia: a pharmacovigilance study of the United States Food and Drug Administration's Adverse Event Reporting System database.Frontiers in pharmacology · 2025Article
- Pharmacokinetics and exposure-safety relationship of ciprofol for sedation in mechanically ventilated patients in the intensive care unit.CPT: pharmacometrics & systems pharmacology · 2024Article
- Case report: Successful treatment of hyperkalemia during general anesthesia in a domestic cat.Frontiers in veterinary science · 2024Article
- Propofol-Related Infusion Syndrome: A Bibliometric Analysis of the 100 Most-Cited Articles.Cureus · 2023Review
- Unusual case of propofol-related infusion syndrome complicating severe COVID-19 ARDS.BMJ case reports · 2023Article
- Successful treatment of propofol-related infusion syndrome in critically ill patient receiving low-dose propofol infusion: a case report.Acute and critical care · 2023Article
- Long-term sedation with remimazolam besylate versus propofol in critically ill patients during invasive mechanical ventilation: a study protocol for a multicenter randomized non-inferior trial.Frontiers in pharmacology · 2023Article
- Balanced volatile sedation with isoflurane in critically ill patients with aneurysmal subarachnoid hemorrhage - a retrospective observational study.Frontiers in neurology · 2023Article
- Article
- Propofol infusion syndrome & COVID-19 in a victim of multiple gunshot wounds: Diagnostic and therapeutic dilemmas.Trauma case reports · 2022Article
- Review
10 more citing papers are in PubMed but not listed here.
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Authors and funding
17 authors at 13 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionWhile propofol is associated with an infusion syndrome (PRIS) that may cause death, the incidence of PRIS is unknown. Determining the incidence of PRIS and the frequency of PRIS-related clinical manifestations are key steps prior to the completion of any controlled studies investigating PRIS. This prospective, multicenter study sought to determine the incidence of PRIS and PRIS-related clinical manifestations in a large cohort of critically ill adults prescribed propofol.
methodsCritically ill adults from 11 academic medical centers administered an infusion of propofol for [>or=] 24 hours were monitored at baseline and then on a daily basis until propofol was discontinued for the presence of 11 different PRIS-associated clinical manifestations and risk factors derived from 83 published case reports of PRIS.
resultsAmong 1017 patients [medical (35%), neurosurgical (25%)], PRIS (defined as metabolic acidosis plus cardiac dysfunction and [>or=] 1 of: rhabdomyolysis, hypertriglyceridemia or renal failure occurring after the start of propofol therapy) developed in 11 (1.1%) patients an average of 3 (1-6) [median (range)] days after the start of propofol. While most (91%) of the patients who developed PRIS were receiving a vasopressor (80% initiated after the start of propofol therapy), few received a propofol dose >83 mcg/kg/min (18%) or died (18%). Compared to the 1006 patients who did not develop PRIS, the APACHE II score (25 +/- 6 vs 20 +/- 7, P = 0.01) was greater in patients with PRIS but both the duration of propofol use (P = 0.43) and ICU length of stay (P = 0.82) were similar.
conclusionsDespite using a conservative definition for PRIS, and only considering new-onset PRIS clinical manifestations, the incidence of PRIS slightly exceeds 1%. Future controlled studies focusing on evaluating whether propofol manifests the derangements of critical illness more frequently than other sedatives will need to be large. These studies should also investigate the mechanism(s) and risk factors for PRIS.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.