ArticleThe Journal of organic chemistry2009
A practical total synthesis of globo-H for use in anticancer vaccines.
Article in The Journal of organic chemistry, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 38 citations in OpenAlex.
- Synthesis of Azido-Globo H Analogs for Immunogenicity Evaluation.ACS central science · 2022Article
- Automated Chemical Oligosaccharide Synthesis: Novel Approach to Traditional Challenges.Chemical reviews · 2018Review
- ABO Antigens Active Tri- and Disaccharides Microarray to Evaluate C-type Lectin Receptor Binding Preferences.Scientific reports · 2018Article
- Antibody repertoire profiling with mimotope arrays.Human vaccines & immunotherapeutics · 2017Article
- Sequential One-Pot Multienzyme Chemoenzymatic Synthesis of Glycosphingolipid Glycans.The Journal of organic chemistry · 2016Article
- Human Cancer Antigen Globo H Is a Cell-Surface Ligand for Human Ribonuclease 1.ACS central science · 2015Article
- Affinity of monoclonal antibodies for Globo-series glycans.Carbohydrate research · 2014Article
- A vision for vaccines built from fully synthetic tumor-associated antigens: from the laboratory to the clinic.Journal of the American Chemical Society · 2013Article
- 2-Allylphenyl glycosides as complementary building blocks for oligosaccharide and glycoconjugate synthesis.Beilstein journal of organic chemistry · 2012Article
- On orthogonal and selective activation of glycosyl thioimidates and thioglycosides: application to oligosaccharide assembly.The Journal of organic chemistry · 2011Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
An improved synthesis of the hexasaccharide MBr1 antigen (globo-H) is reported. Enhanced efficiency in the synthesis was necessary for the scale-up production of globo-H, in order to advance globo-H-based anticancer vaccines to clinical trials. The key features of the improved synthesis include preactivation-based glycosylations and a revised iodosulfonimidation/rearrangement.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.