ArticleAnalytical chemistry2009
Rapid determination of RNA accessible sites by surface plasmon resonance detection of hybridization to DNA arrays.
Article in Analytical chemistry, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 26 citations in OpenAlex.
- In Vivo Detection of miRNA Expression in Tumors Using an Activatable Nanosensor.Molecular imaging and biology · 2016Article
- Efficient Design of Compact Unstructured RNA Libraries Covering All k-mers.Journal of computational biology : a journal of computational molecular cell biology · 2016Article
- Carbon Substrates: A Stable Foundation for Biomolecular Arrays.Annual review of analytical chemistry (Palo Alto, Calif.) · 2015Review
- Short loop-targeting oligoribonucleotides antagonize Lin28 and enable pre-let-7 processing and suppression of cell growth in let-7-deficient cancer cells.Nucleic acids research · 2015Article
- Detection of miRNA expression in intact cells using activatable sensor oligonucleotides.Chemistry & biology · 2014Article
- On-chip synthesis of protein microarrays from DNA microarrays via coupled in vitro transcription and translation for surface plasmon resonance imaging biosensor applications.Journal of the American Chemical Society · 2012Article
- Current approaches to micro-RNA analysis and target gene prediction.Journal of applied genetics · 2012Review
- Sensitive and label-free biosensing of RNA with predicted secondary structures by a triplex affinity capture method.Nucleic acids research · 2012Article
- Interface design and multiplexed analysis with surface plasmon resonance (SPR) spectroscopy and SPR imaging.The Analyst · 2010Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
RNA accessible sites are the regions in an RNA molecule that are available for hybridization with cDNA or RNA molecules. The identification of these accessible sites is a critical first step in identifying antisense-mediated gene suppression sites, as well as in a variety of other RNA-based analysis methods. Here, we present a rapid, hybridization-based, label-free method of identifying RNA accessible sites with surface plasmon resonance imaging (SPRi) on in situ synthesized oligonucleotide arrays prepared on carbon-on-metal substrates. The accessible sites of three pre-miRNAs, miRNA precursors of approximately 75 nt in length, were determined by hybridizing the RNA molecules to RNA-specific tiling arrays. An array composed of all possible 6mer oligonucleotide sequences was also utilized in this work, offering a universal platform capable of studying RNA molecules in a high throughput manner.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.