ArticleCellular and molecular bioengineering2008
Effects of the Tumor-Leukocyte Microenvironment on Melanoma-Neutrophil Adhesion to the Endothelium in a Shear Flow.
Article in Cellular and molecular bioengineering, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 30 citations in OpenAlex.
- The pan-immune-inflammation value predicts prognosis and chemotherapy-related adverse events in Wilms' tumor patients.BMC cancer · 2025Article
- Article
- Role of neutrophil extracellular traps in regulation of lung cancer invasion and metastasis: Structural insights from a computational model.PLoS computational biology · 2021Article
- Optimization of BCG Therapy Targeting Neutrophil Extracellular Traps, Autophagy, and miRNAs in Bladder Cancer: Implications for Personalized Medicine.Frontiers in medicine · 2021Review
- Multiscalar cellular automaton simulates in-vivo tumour-stroma patterns calibrated from in-vitro assay data.BMC medical informatics and decision making · 2017Article
- Review
- NETopathies? Unraveling the Dark Side of Old Diseases through Neutrophils.Frontiers in immunology · 2016Review
- Multi-scale biological and physical modelling of the tumour micro-environment.Drug discovery today. Disease models · 2015Article
- Pivotal role of pervasive neoplastic and stromal cells reprogramming in circulating tumor cells dissemination and metastatic colonization.Cancer microenvironment : official journal of the International Cancer Microenvironment Society · 2014Article
- Neutrophil extracellular traps in cancer progression.Cellular and molecular life sciences : CMLS · 2014Review
- Metastasis review: from bench to bedside.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Review
- CD82/KAI expression prevents IL-8-mediated endothelial gap formation in late-stage melanomas.Oncogene · 2014Article
- Investigation of the essential role of platelet-tumor cell interactions in metastasis progression using an agent-based model.Theoretical biology & medical modelling · 2014Article
- Neutrophil extracellular traps sequester circulating tumor cells and promote metastasis.The Journal of clinical investigation · 2013Article
- Using space-based investigations to inform cancer research on Earth.Nature reviews. Cancer · 2013Review
- Fibrin serves as a divalent ligand that regulates neutrophil-mediated melanoma cells adhesion to endothelium under shear conditions.American journal of physiology. Cell physiology · 2012Article
- Myenteric denervation downregulates galectin-1 and -3 expression in gastric carcinogenesis.Digestive diseases and sciences · 2011Article
- Vascular Recruitment of Human Retinoblastoma Cells by Multi-Cellular Adhesive Interactions with Circulating Leukocytes.Cellular and molecular bioengineering · 2010Article
- Application of Population Dynamics to Study Heterotypic Cell Aggregations in the Near-Wall Region of a Shear Flow.Cellular and molecular bioengineering · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
The primary cause of cancer mortality is not attributed to primary tumor formation, but rather to the growth of metastases at distant organ sites. Tumor cell adhesion to blood vessel endothelium (EC) and subsequent transendothelial migration within the circulation are critical components of the metastasis cascade. Previous studies have shown polymorphonuclear neutrophils (PMNs) may facilitate melanoma cell adhesion to the EC and subsequent extravasation under flow conditions. The melanoma cell-PMN interactions are found to be mediated by the binding between intercellular adhesion molecule-1 (ICAM-1) on melanoma cells and β(2) integrin on PMNs and by endogenously secreted interleukin 8 (IL-8) within the tumor-leukocyte microenvironment. In this study, the effects of fluid convection on the IL-8-mediated activation of PMNs and the binding kinetics between PMNs and melanoma cells were investigated. Results indicate that the shear rate dependence of PMN-melanoma cell adhesion and melanoma cell extravasation is due, at least partly, to the convection of tumor-secreted proinflammatory cytokine IL-8.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.