ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2009
Differential gene expression in the developing lateral geniculate nucleus and medial geniculate nucleus reveals novel roles for Zic4 and Foxp2 in visual and auditory pathway development.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 51 citations in OpenAlex.
- Genetic correlations and genome-wide associations of cortical structure in general population samples of 22,824 adults.Nature communications · 2020Pooled it
- Development of the early fetal human thalamus: from a protomap to emergent thalamic nuclei.Frontiers in neuroanatomy · 2025Article
- Harmony in the Molecular Orchestra of Hearing: Developmental Mechanisms from the Ear to the Brain.Annual review of neuroscience · 2024Review
- Trade-Offs in the Sensory Brain between Diurnal and Nocturnal Rodents.Brain, behavior and evolution · 2024Article
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- Structural and functional asymmetry of the neonatal cerebral cortex.Nature human behaviour · 2023Article
- Cross-hierarchical plasticity of corticofugal projections to dLGN after neonatal monocular enucleation.The Journal of comparative neurology · 2022Article
- The genetic architecture of structural left-right asymmetry of the human brain.Nature human behaviour · 2021Article
- Region-specific Foxp2 deletions in cortex, striatum or cerebellum cannot explain vocalization deficits observed in spontaneous global knockouts.Scientific reports · 2020Article
- Innate connectivity patterns drive the development of the visual word form area.Scientific reports · 2020Article
- Sox2 Acts in Thalamic Neurons to Control the Development of Retina-Thalamus-Cortex Connectivity.iScience · 2019Article
- MiR-34a Regulates Axonal Growth of Dorsal Root Ganglia Neurons by Targeting FOXP2 and VAT1 in Postnatal and Adult Mouse.Molecular neurobiology · 2018Article
- Identification of the neurotransmitter profile of AmFoxP expressing neurons in the honeybee brain using double-label in situ hybridization.BMC neuroscience · 2018Article
- Visual Experience-Dependent Expression of Fn14 Is Required for Retinogeniculate Refinement.Neuron · 2018Article
- Genetic Labeling of Nuclei-Specific Thalamocortical Neurons Reveals Putative Sensory-Modality Specific Genes.Cerebral cortex (New York, N.Y. : 1991) · 2017Article
- Connectivity precedes function in the development of the visual word form area.Nature neuroscience · 2016Article
- Transcriptional maturation of the mouse auditory forebrain.BMC genomics · 2015Article
- Possible functional links among brain- and skull-related genes selected in modern humans.Frontiers in psychology · 2015Article
- Ten-m2 is required for the generation of binocular visual circuits.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- The organization and physiology of the auditory thalamus and its role in processing acoustic features important for speech perception.Brain and language · 2013Review
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
Primary sensory nuclei of the thalamus process and relay parallel channels of sensory input into the cortex. The developmental processes by which these nuclei acquire distinct functional roles are not well understood. To identify novel groups of genes with a potential role in differentiating two adjacent sensory nuclei, we performed a microarray screen comparing perinatal gene expression in the principal auditory relay nucleus, the medial geniculate nucleus (MGN), and principal visual relay nucleus, the lateral geniculate nucleus (LGN). We discovered and confirmed groups of highly ranked, differentially expressed genes with qRT-PCR and in situ hybridization. A functional role for Zic4, a transcription factor highly enriched in the LGN, was investigated using Zic4-null mice, which were found to have changes in topographic patterning of retinogeniculate projections. Foxp2, a transcriptional repressor expressed strongly in the MGN, was found to be positively regulated by activity in the MGN. These findings identify roles for two differentially expressed genes, Zic4 and Foxp2, in visual and auditory pathway development. Finally, to test whether modality-specific patterns of gene expression are influenced by extrinsic patterns of input, we performed an additional microarray screen comparing the normal MGN to "rewired" MGN, in which normal auditory afferents are ablated and novel retinal inputs innervate the MGN. Data from this screen indicate that rewired MGN acquires some patterns of gene expression that are present in the developing LGN, including an upregulation of Zic4 expression, as well as novel patterns of expression which may represent unique processes of cross-modal plasticity.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.