Trial reportThe Journal of clinical endocrinology and metabolism2010
Effect of short-term free Fatty acids elevation on mitochondrial function in skeletal muscle of healthy individuals.
Trial report in The Journal of clinical endocrinology and metabolism, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed, 51 citations in OpenAlex.
- Lipids activate skeletal muscle mitochondrial fission and quality control networks to induce insulin resistance in humans.Metabolism: clinical and experimental · 2021Trial
- Electrical Pulse Stimulation Partially Restores Insulin Signaling in Palmitate-Induced Insulin-Resistant Skeletal Muscle Cells via Mitochondrial Remodeling and Contractile Activity-Dependent Secretome.Journal of cellular physiology · 2026Article
- Intermuscular Adipose Tissue in CKD: A Window into Muscle Quality and Health?Clinical journal of the American Society of Nephrology : CJASN · 2025Review
- Long Noncoding RNAs in the Pathogenesis of Insulin Resistance.International journal of molecular sciences · 2022Review
- Impact of moderate exercise on fatty acid oxidation in pancreatic β-cells and skeletal muscle.Journal of endocrinological investigation · 2021Review
- Insulin resistance in obesity: an overview of fundamental alterations.Eating and weight disorders : EWD · 2018Review
- Dicarbonyl Stress and Glyoxalase-1 in Skeletal Muscle: Implications for Insulin Resistance and Type 2 Diabetes.Frontiers in cardiovascular medicine · 2018Review
- Article
- Transcriptomics in type 2 diabetes: Bridging the gap between genotype and phenotype.Genomics data · 2016Article
- ANT1-mediated fatty acid-induced uncoupling as a target for improving myocellular insulin sensitivity.Diabetologia · 2016Article
- Serum Vitamin D Concentrations in Baboons (Papio spp.) during Pregnancy and Obesity.Comparative medicine · 2016Article
- Postprandial Metabolism of Macronutrients and Cardiometabolic Risk: Recent Developments, Emerging Concepts, and Future Directions.Advances in nutrition (Bethesda, Md.) · 2016Review
- Rapid development of cardiac dysfunction in a canine model of insulin resistance and moderate obesity.Diabetologia · 2016Article
- Elevated nocturnal NEFA are an early signal for hyperinsulinaemic compensation during diet-induced insulin resistance in dogs.Diabetologia · 2015Article
- Lipid-induced insulin resistance does not impair insulin access to skeletal muscle.American journal of physiology. Endocrinology and metabolism · 2015Article
- Sleep restriction increases free fatty acids in healthy men.Diabetologia · 2015Article
- TRIM24 suppresses development of spontaneous hepatic lipid accumulation and hepatocellular carcinoma in mice.Journal of hepatology · 2015Article
- Effects of acute lipid overload on skeletal muscle insulin resistance, metabolic flexibility, and mitochondrial performance.American journal of physiology. Endocrinology and metabolism · 2014Article
- Exercise training decreases activation of the mitochondrial fission protein dynamin-related protein-1 in insulin-resistant human skeletal muscle.Journal of applied physiology (Bethesda, Md. : 1985) · 2014Article
- Article
Corrections and comments
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Authors and funding
14 authors at 1 institution in 1 country.
Funding
Abstract
contextMitochondrial dysfunction has been proposed as an underlying mechanism in the pathogenesis of insulin resistance and type 2 diabetes mellitus.
objectiveTo determine whether mitochondrial dysfunction plays a role in the free fatty acid (FFA)-induced impairment in insulin action in skeletal muscle of healthy subjects.
designEleven lean normal glucose tolerant individuals received 8 h lipid and saline infusion on separate days with a euglycemic insulin clamp during the last 2 h. Vastus lateralis muscle biopsies were performed at baseline and after 6 h lipid or saline infusion. Inner mitochondrial membrane potential (Psi(m)) and mitochondrial mass were determined ex vivo by confocal microscopy.
resultsCompared with saline infusion, lipid infusion reduced whole-body glucose uptake by 22% (P < 0.05). Psi(m) decreased by 33% (P < 0.005) after lipid infusion and the decrement in Psi(m) correlated with change in plasma FFA after lipid infusion (r = 0.753; P < 0.005). Mitochondrial content and morphology did not change after lipid infusion. No significant changes in genes expression, citrate synthase activity, and total ATP content were observed after either lipid or saline infusion.
conclusionsShort-term physiological increase in plasma FFA concentration in lean normal glucose tolerant subjects induces insulin resistance and impairs mitochondrial membrane potential but has no significant effects on mitochondrial content, gene expression, ATP content, or citrate synthase activity.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.