ArticleThe Journal of biological chemistry2009
A novel xylosylphosphotransferase activity discovered in Cryptococcus neoformans.
Article in The Journal of biological chemistry, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Identification of a putative α-galactoside β-(1 → 3)-galactosyltransferase involved in the biosynthesis of galactomannan side chain of glucuronoxylomannogalactan inFrontiers in microbiology · 2024Article
- Gene Silencing via RNA Interference in Cryptococcus.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Nucleotide Sugars in Chemistry and Biology.Molecules (Basel, Switzerland) · 2020Review
- Peeling the onion: the outer layers of Cryptococcus neoformans.Memorias do Instituto Oswaldo Cruz · 2018Review
- Gene Regulatory Networks for the Haploid-to-Diploid Transition ofPlant physiology · 2017Article
- Virulence Factors as Targets for Anticryptococcal Therapy.Journal of fungi (Basel, Switzerland) · 2016Review
- ALL2, a Homologue of ALL1, Has a Distinct Role in Regulating pH Homeostasis in the Pathogen Cryptococcus neoformans.Infection and immunity · 2016Article
- Virulence-Associated Enzymes of Cryptococcus neoformans.Eukaryotic cell · 2015Review
- Analysis of mucolipidosis II/III GNPTAB missense mutations identifies domains of UDP-GlcNAc:lysosomal enzyme GlcNAc-1-phosphotransferase involved in catalytic function and lysosomal enzyme recognition.The Journal of biological chemistry · 2015Article
- The Role of Amino Acid Permeases and Tryptophan Biosynthesis in Cryptococcus neoformans Survival.PloS one · 2015Article
- Cryptococcus neoformans dual GDP-mannose transporters and their role in biology and virulence.Eukaryotic cell · 2014Article
- Pbx proteins in Cryptococcus neoformans cell wall remodeling and capsule assembly.Eukaryotic cell · 2014Article
- RNA interference in Cryptococcus neoformans.Methods in molecular biology (Clifton, N.J.) · 2012Article
- Efficient implementation of RNA interference in the pathogenic yeast Cryptococcus neoformans.Journal of microbiological methods · 2011Article
- A xylosylphosphotransferase of Cryptococcus neoformans acts in protein O-glycan synthesis.The Journal of biological chemistry · 2011Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Cryptococcus neoformans is a fungal pathogen that causes serious disease in immunocompromised individuals. The organism produces a distinctive polysaccharide capsule that is necessary for its virulence, a predominantly polysaccharide cell wall, and a variety of protein- and lipid-linked glycans. The glycan synthetic pathways of this pathogen are of great interest. Here we report the detection of a novel glycosylphosphotransferase activity in C. neoformans, identification of the corresponding gene, and characterization of the encoded protein. The observed activity is specific for UDP-xylose as a donor and for mannose acceptors and forms a xylose-alpha-1-phosphate-6-mannose linkage. This is the first report of a xylosylphosphotransferase activity in any system.
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