ReviewJournal of the Royal Society, Interface2010
Bone tissue engineering therapeutics: controlled drug delivery in three-dimensional scaffolds.
Review in Journal of the Royal Society, Interface, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 112 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
112 citing papers in PubMed.
- From bone replacement to regeneration. A biomaterials started journey.Materials today. Bio · 2026Review
- Injectable sustained local release doxorubicin depot technology- a promising adjuvant to systemic treatment?Drug delivery and translational research · 2025Article
- Polycaprolactone/Doped Bioactive Glass Composite Scaffolds for Bone Regeneration.Journal of functional biomaterials · 2025Article
- Biomaterial Cues for Regulation of Osteoclast Differentiation and Function in Bone Regeneration.Advanced therapeutics · 2025Article
- Calcium phosphate-based anti-infective bone cements: recent trends and future perspectives.Frontiers in pharmacology · 2025Review
- Application and progress of 3D printed biomaterials in osteoporosis.Frontiers in bioengineering and biotechnology · 2025Review
- Bone scaffolds-based localized drugs delivery for osteosarcoma: current status and future perspective.Drug delivery · 2024Review
- Advances in magnesium-containing bioceramics for bone repair.Biomaterials translational · 2024Review
- Article
- Curcumin and resveratrol delivery from multi-functionalized calcium phosphate scaffold enhances biological properties.Journal of drug delivery science and technology · 2023Article
- Fracture mechanism and mechanical properties of porous HA/PLCL and HA/PLLA sandwich composite beams.In vitro models · 2023Article
- Article
- The Concept of Scaffold-Guided Bone Regeneration for the Treatment of Long Bone Defects: Current Clinical Application and Future Perspective.Journal of functional biomaterials · 2023Review
- Microporous/Macroporous Polycaprolactone Scaffolds for Dental Applications.Pharmaceutics · 2023Article
- Microporous Implants Modified by Bifunctional Hydrogel with Antibacterial and Osteogenic Properties Promote Bone Integration in Infected Bone Defects.Journal of functional biomaterials · 2023Article
- 3D printing method for bone tissue engineering scaffold.Medicine in novel technology and devices · 2023Article
- The Role of Microsphere Structures in Bottom-Up Bone Tissue Engineering.Pharmaceutics · 2023Review
- A microfluidic-based approach to investigate the inflammatory response of macrophages to pristine and drug-loaded nanostructured hydroxyapatite.Materials today. Bio · 2022Article
- Synthesis, physical properties, and biomedical applications of magnetic nanoparticles: a review.Progress in biomaterials · 2022Review
- Scaffolds in the microbial resistant era: Fabrication, materials, properties and tissue engineering applications.Materials today. Bio · 2022Review
52 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This paper provides an extensive overview of published studies on the development and applications of three-dimensional bone tissue engineering (TE) scaffolds with potential capability for the controlled delivery of therapeutic drugs. Typical drugs considered include gentamicin and other antibiotics generally used to combat osteomyelitis, as well as anti-inflammatory drugs and bisphosphonates, but delivery of growth factors is not covered in this review. In each case reviewed, special attention has been given to the technology used for controlling the release of the loaded drugs. The possibility of designing multifunctional three-dimensional bone TE scaffolds for the emerging field of bone TE therapeutics is discussed. A detailed summary of drugs included in three-dimensional scaffolds and the several approaches developed to combine bioceramics with various polymeric biomaterials in composites for drug-delivery systems is included. The main results presented in the literature are discussed and the remaining challenges in the field are summarized with suggestions for future research directions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.