Trial reportArchives of environmental & occupational health2009
Interaction of ambient air pollution with asthma medication on exhaled nitric oxide among asthmatics.
Trial report in Archives of environmental & occupational health, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed.
- Adrenergic receptor subtypes differentially influence acrolein-induced ventilatory, vascular leakage, and inflammatory responses.Toxicology and applied pharmacology · 2025Article
- Inhaled Corticosteroids Attenuate the Association of Fine Particulate Matter and Acute Asthma Events.American journal of respiratory and critical care medicine · 2024Article
- Nitrogen Dioxide Pollutant Exposure and Exercise-induced Bronchoconstriction in Urban Childhood Asthma: A Pilot Study.Annals of the American Thoracic Society · 2022Article
- Independent roles of beta-adrenergic and glucocorticoid receptors in systemic and pulmonary effects of ozone.Inhalation toxicology · 2020Article
- Susceptibility Variations in Air Pollution Health Effects: Incorporating Neuroendocrine Activation.Toxicologic pathology · 2019Article
- Exacerbation of ozone-induced pulmonary and systemic effects by βScientific reports · 2019Article
- Ambient air pollution, asthma drug response, and telomere length in African American youth.The Journal of allergy and clinical immunology · 2019Article
- Beta-2 Adrenergic and Glucocorticoid Receptor Agonists Modulate Ozone-Induced Pulmonary Protein Leakage and Inflammation in Healthy and Adrenalectomized Rats.Toxicological sciences : an official journal of the Society of Toxicology · 2018Article
- The level of submicron fungal fragments in homes with asthmatic children.Environmental research · 2014Article
- Noninvasive effects measurements for air pollution human studies: methods, analysis, and implications.Journal of exposure science & environmental epidemiologyReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
The interaction between ambient air pollution and asthma medication remains unclear. The authors compared airway inflammation response to air pollution among asthmatics. Increases of 10 ppb of nitrogen dioxide (NO2) and of 10 microg/m3 of particulate matter < 10 micron in diameter (PM10) daily concentrations were associated with an increase in exhaled nitric oxide (eNO) of 0.13 ppb (95% confidence interval = 0.06, 0.19) and of 0.07 ppb (95% confidence interval = 0.02, 0.12), respectively, in models adjusted for important covariates. The results show that the medication could not counteract airway inflammation effects of air pollution. Specifically, the patients on triamcinolone decreased the sensitivity to PM10 but increased the sensitivity to NO2. The patients on salmeterol were more vulnerable to both NO2 and PM10. This study indicates that the current pollution levels may still enhance airway inflammation among patients with persistent asthma even when they are on asthma medications.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.