ReviewCurrent opinion in microbiology2009
Prion dynamics and the quest for the genetic determinant in protein-only inheritance.
Review in Current opinion in microbiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed.
- Beyond Amyloid Fibers: Accumulation, Biological Relevance, and Regulation of Higher-Order Prion Architectures.Viruses · 2022Review
- A structured model and likelihood approach to estimate yeast prion propagon replication rates and their asymmetric transmission.PLoS computational biology · 2022Article
- Extracellular Vesicles and the Propagation of Yeast Prions.Current topics in microbiology and immunology · 2021Article
- Extracellular Vesicles-Encapsulated Yeast Prions and What They Can Tell Us about the Physical Nature of Propagons.International journal of molecular sciences · 2020Review
- A unifying model for the propagation of prion proteins in yeast brings insight into the [PSI+] prion.PLoS computational biology · 2020Article
- How and why to build a mathematical model: A case study using prion aggregation.The Journal of biological chemistry · 2020Review
- Generalizing a mathematical model of prion aggregation allows strain coexistence and co-stability by including a novel misfolded species.Journal of mathematical biology · 2019Article
- A numerical scheme for the early steps of nucleation-aggregation models.Journal of mathematical biology · 2017Article
- A mathematical model of the dynamics of prion aggregates with chaperone-mediated fragmentation.Journal of mathematical biology · 2016Article
- A Study in Nucleated Polymerization Models of Protein Aggregation.Applied mathematics letters · 2015Article
- Visualization of transient protein-protein interactions that promote or inhibit amyloid assembly.Molecular cell · 2014Article
- Chaperone proteins select and maintain [PIN+] prion conformations in Saccharomyces cerevisiae.The Journal of biological chemistry · 2013Article
- A Discrete-Time Branching Process Model of Yeast Prion Curing Curves.Mathematical population studies · 2013Article
- Understanding the complex mechanisms of β2-microglobulin amyloid assembly.The FEBS journal · 2011Review
- [SWI], the prion formed by the chromatin remodeling factor Swi1, is highly sensitive to alterations in Hsp70 chaperone system activity.PLoS genetics · 2011Article
- Conformational conversion during amyloid formation at atomic resolution.Molecular cell · 2011Article
- The prion hypothesis: from biological anomaly to basic regulatory mechanism.Nature reviews. Molecular cell biology · 2010Review
- A size threshold limits prion transmission and establishes phenotypic diversity.Science (New York, N.Y.) · 2010Article
- Insights into prion biology: integrating a protein misfolding pathway with its cellular environment.PrionArticle
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
According to the prion hypothesis, proteins may act in atypical roles as genetic elements of infectivity and inheritance by undergoing self-replicating changes in physical state. While the preponderance of evidence strongly supports this concept particularly in fungi, the detailed mechanisms by which distinct protein forms specify unique phenotypes are emerging concepts. A particularly active area of investigation is the molecular nature of the heritable species, which has been probed through genetic, biochemical, and cell biological experimentation as well as by mathematical modeling. Here, we suggest that these studies are converging to implicate small aggregates composed of prion-state conformers as the transmissible genetic determinants of protein-based phenotypes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.