ReviewCurrent cardiology reports2009
The current state of RAAS blockade in the treatment of hypertension and proteinuria.
Review in Current cardiology reports, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed.
- Treatment of Hypertension in Chronic Kidney Disease.Current hypertension reports · 2018Review
- Dietary tetrahydrocurcumin reduces renal fibrosis and cardiac hypertrophy in 5/6 nephrectomized rats.Pharmacology research & perspectives · 2018Article
- Dual Blockade of the Renin-angiotensin-aldosterone System in Type 2 Diabetic Kidney Disease.Chinese medical journal · 2016Review
- Marketed nonsteroidal anti-inflammatory agents, antihypertensives, and human immunodeficiency virus protease inhibitors: as-yet-unused weapons of the oncologists' arsenal.Therapeutics and clinical risk management · 2015Review
- Elevated ecto-5'-nucleotidase-mediated increased renal adenosine signaling via A2B adenosine receptor contributes to chronic hypertension.Circulation research · 2013Article
- Angiotensin receptor blockers: pharmacology, efficacy, and safety.Journal of clinical hypertension (Greenwich, Conn.) · 2011Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hypertension is a well-established risk factor for cardiovascular disease (CVD) and chronic kidney disease (CKD). Patients with CKD have significant morbidity (ie, increased risk of CVD) and progression to end-stage renal disease. Increase in albuminuria over time to levels greater than 300 mg/d, in spite of blood pressure being at goal, is an independent predictor for nephropathy progression. Data provide support, however, for reducing proteinuria by at least 30% after treatment is initiated in patients with proteinuria. Pharmacologic blockade of the renin-angiotensin-aldosterone system (RAAS) slows progression of advanced proteinuric CKD more effectively than other antihypertensive agents. In post hoc analyses, this slowed progression has been correlated to reductions in proteinuria of 30% or more after blood pressure-lowering therapy is initiated. Increases in proteinuria, in spite of blood pressure reduction, are associated with faster declines in kidney function regardless of whether RAAS blockers are used.
Indexed as
Identifiers
19863868What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.