ReviewCritical care (London, England)2009
Clinical review: Goal-directed therapy in high risk surgical patients.
Review in Critical care (London, England), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01681238 (A Randomized Study of Goal-directed Therapy in the Elderly High-risk Patients Undergoing Total Hip Replacement), which is not on this map. Cited by 36 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Randomized Study of Goal-directed Therapy in the Elderly High-risk Patients Undergoing Total Hip Replacement
Who cites it
36 citing papers in PubMed, 2 syntheses or guidelines pooled it, 130 citations in OpenAlex.
- Perioperative fluid volume optimization following proximal femoral fracture.The Cochrane database of systematic reviews · 2016Pooled it
- Haemodynamic goal-directed therapy and postoperative infections: earlier is better. A systematic review and meta-analysis.Critical care (London, England) · 2011Pooled it
- Implications of Continuous Noninvasive Finger Cuff Arterial Pressure Device Use during Cesarean Delivery for Goal-Directed Fluid Therapy Preload Optimization: A Randomized Controlled Trial.BioMed research international · 2021Trial
- Impact of early haemodynamic goal-directed therapy in patients undergoing emergency surgery: an open prospective, randomised trial.Journal of clinical monitoring and computing · 2016Trial
- Goal-Directed Fluid Therapy Using Stroke Volume Variation for Resuscitation after Low Central Venous Pressure-Assisted Liver Resection: A Randomized Clinical Trial.Journal of the American College of Surgeons · 2015Trial
- A randomized trial of goal directed vs. standard fluid therapy in cytoreductive surgery with hyperthermic intraperitoneal chemotherapy.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2015Trial
- Goal-directed fluid therapy in gastrointestinal surgery in older coronary heart disease patients: randomized trial.World journal of surgery · 2013Trial
- Outcome impact of goal directed fluid therapy during high risk abdominal surgery in low to moderate risk patients: a randomized controlled trial.Journal of clinical monitoring and computing · 2013Trial
- Goal-directed intraoperative fluid therapy guided by stroke volume and its variation in high-risk surgical patients: a prospective randomized multicentre study.Journal of clinical monitoring and computing · 2013Trial
- Central venous O₂ saturation and venous-to-arterial CO₂ difference as complementary tools for goal-directed therapy during high-risk surgery.Critical care (London, England) · 2010Trial
- Non-Invasive Cardiac Output Monitoring with Electrical Cardiometry During Laparoscopic Cholecystectomy Surgery, a Cross-Sectional Study.Journal of clinical medicine · 2025Article
- The Hypotension Prediction Index in Free Flap Transplant in Head and Neck Surgery: Protocol of a Prospective Randomized Controlled Trial.Life (Basel, Switzerland) · 2025Article
- Testing an inverse modeling approach with gradient boosting regression for stroke volume estimation using patient thermodilution data.Frontiers in artificial intelligence · 2025Article
- Role of Crystalloids in the Perioperative Setting: From Basics to Clinical Applications and Enhanced Recovery Protocols.Journal of clinical medicine · 2023Review
- Cardiac output estimated from an uncalibrated radial blood pressure waveform: validation in anFrontiers in bioengineering and biotechnology · 2023Article
- Optimization of the target strategy of perioperative infusion therapy based on monitoring data of central hemodynamics in order to prevent complications.Frontiers in medicine · 2022Review
- Evaluation of the relationship between lactacidemia and postoperative complications after surgery for peritoneal carcinomatosis.Korean journal of anesthesiology · 2021Observational
- Observational
- Noninvasive estimation of aortic hemodynamics and cardiac contractility using machine learning.Scientific reports · 2020Article
- Perioperative Fluid Administration in Pancreatic Surgery: a Comparison of Three Regimens.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2020Observational
Corrections and comments
- Commented on by
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A small group of patients account for the majority of peri-operative morbidity and mortality. These 'high-risk' patients have a poor outcome due to their inability to meet the oxygen transport demands imposed on them by the nature of the surgical response during the peri-operative period. It has been shown that by targeting specific haemodynamic and oxygen transport goals at any point during the peri-operative period, the outcomes of these patients can be improved. This goal directed therapy includes the use of fluid loading and inotropes, in order to optimize the preload, contractility and afterload of the heart whilst maintaining an adequate coronary perfusion pressure. Despite the benefits seen, it remains a challenge to implement this management due to difficulties in identifying these patients, scepticism and lack of critical care resources.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.