Evidence map›Paper›PMID 19863762›Full record

ArticleJournal of biology2009

Targeting TNF-alpha for cancer therapy.

Elizabeth R Burton, Steven K Libutti

Open access · goldAbstract read
In one paragraph

Article in Journal of biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 31 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Expression profile of apoptosis-related genes potentially explains early recurrence after definitive chemoradiation in esophageal squamous cell carcinoma.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Prognostic significance of TRAIL signaling molecules in stage II and III colorectal cancer.Clinical cancer research : an official journal of the American Association for Cancer Research · 2010
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Elizabeth R BurtonMontefiore Medical Center, Medical Arts Pavilion, 3400 Bainbridge Avenue, MMC-MAP, Bronx, NY 10467, USA.
Steven K Libutti
Montefiore Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

As the tumor vasculature is a key element of the tumor stroma, angiogenesis is the target of many cancer therapies. Recent work published in BMC Cell Biology describes a fusion protein that combines a peptide previously shown to home in on the gastric cancer vasculature with the anti-tumor cytokine TNF-alpha, and assesses its potential for gastric cancer therapy.

Indexed as

Drug Delivery SystemsGenetic TherapyAngiogenesis InhibitorsAnimalsApoptosisEndothelium, VascularGene Expression Regulation, NeoplasticHumansMiceNeoplasmsNeovascularization, PathologicRNA, Small InterferingSignal TransductionStomach NeoplasmsTumor Necrosis Factor-alphaAngiogenesis InhibitorsRNA, Small InterferingTumor Necrosis Factor-alpha

Identifiers

PMID19863762
PMCPMC2776910
OpenAlexW2165573420

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.