ArticleSynapse (New York, N.Y.)2010
Early exposure to haloperidol or olanzapine induces long-term alterations of dendritic form.
Article in Synapse (New York, N.Y.), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 52 citations in OpenAlex.
- How Early-Life Antipsychotic Drug Administration Modifies Behavioral and Brain Function in Adulthood.Current topics in behavioral neurosciences · 2025Review
- Olanzapine enhances early brain maturation through activation of the NODAL/FOXH1 axis.iScience · 2024Article
- Long-term effects of adolescent exposure to olanzapine in C57BL/6 J mice and the impact of dietary fish oil supplementation.Psychopharmacology · 2022Article
- The effects of amphetamine on working memory and locomotor activity in adult rats administered risperidone early in life.Behavioural brain research · 2019Article
- Dopamine DBehavioural brain research · 2019Article
- Propionate Protects Haloperidol-Induced Neurite Lesions Mediated by Neuropeptide Y.Frontiers in neuroscience · 2018Article
- Early Antipsychotic Treatment in Juvenile Rats Elicits Long-Term Alterations to the Dopamine Neurotransmitter System.International journal of molecular sciences · 2016Article
- Aerobic Exercise as a Tool to Improve Hippocampal Plasticity and Function in Humans: Practical Implications for Mental Health Treatment.Frontiers in human neuroscience · 2016Review
- Olanzapine antipsychotic treatment of adolescent rats causes long term changes in glutamate and GABA levels in the nucleus accumbens.Schizophrenia research · 2015Article
- Effects of ethanol exposure and withdrawal on dendritic morphology and spine density in the nucleus accumbens core and shell.Brain research · 2015Article
- Antipsychotic drug effects in schizophrenia: a review of longitudinal FMRI investigations and neural interpretations.Current medicinal chemistry · 2013Review
- Olanzapine treatment of adolescent rats causes enduring specific memory impairments and alters cortical development and function.PloS one · 2013Article
- Experience and the developing prefrontal cortex.Proceedings of the National Academy of Sciences of the United States of America · 2012Review
- Brain plasticity and behaviour in the developing brain.Journal of the Canadian Academy of Child and Adolescent Psychiatry = Journal de l'Academie canadienne de psychiatrie de l'enfant et de l'adolescent · 2011Article
- Annual Research Review: New frontiers in developmental neuropharmacology: can long-term therapeutic effects of drugs be optimized through carefully timed early intervention?Journal of child psychology and psychiatry, and allied disciplines · 2011Review
- Epigenetics and biomarkers in the staging of neuropsychiatric disorders.Neurotoxicity research · 2010Review
- Trick or treat? neurodevelopmental consequences of pharmacotherapy for affective disorders.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2010Article
- Factors influencing frontal cortex development and recovery from early frontal injury.Developmental neurorehabilitation · 2009Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
Exposure of the developing brain to a wide variety of drugs of abuse (e.g., stimulants, opioids, ethanol, etc.) can induce life-long changes in behavior and neural circuitry. However, the long-term effects of exposure to therapeutic, psychotropic drugs have only recently begun to be appreciated. Antipsychotic drugs are little studied in this regard. Here, we quantitatively analyzed dendritic architecture in adult mice treated with paradigmatic typical- (haloperidol) or atypical (olanzapine) antipsychotic drugs at developmental stages corresponding to fetal or fetal plus early childhood stages in humans. In layer 3 pyramidal cells of the medial and orbital prefrontal cortices and the parietal cortex and in spiny neurons of the core of the nucleus accumbens, both drugs induced significant changes (predominantly reductions) in the amount and complexity of dendritic arbor and the density of dendritic spines. The drug-induced plasticity of dendritic architecture suggests changes in patterns of neuronal connectivity in multiple brain regions that are likely to be functionally significant.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.