SynthesisRadiation and environmental biophysics2010
Review and meta-analysis of epidemiological associations between low/moderate doses of ionizing radiation and circulatory disease risks, and their possible mechanisms.
Synthesis in Radiation and environmental biophysics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
57 citing papers in PubMed, 4 syntheses or guidelines pooled it, 143 citations in OpenAlex.
- Exposure to low-dose radiation in occupational settings and ischaemic heart disease: a systematic review and meta-analysis.Occupational and environmental medicine · 2023Pooled it
- Radon exposure and risk of cerebrovascular disease: a systematic review and meta-analysis in occupational and general population studies.Environmental science and pollution research international · 2022Pooled it
- Systematic review and meta-analysis of circulatory disease from exposure to low-level ionizing radiation and estimates of potential population mortality risks.Environmental health perspectives · 2012Pooled it
- Efficacy of adjunctive ablation of complex fractionated atrial electrograms and pulmonary vein isolation for the treatment of atrial fibrillation: a meta-analysis of randomized controlled trials.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2011Pooled it
- Indoor Radon Concentrations and Hematologic Traits in the Women's Health Initiative.Epidemiology (Cambridge, Mass.) · 2026Article
- Updated Knowledge on Radon Exposure: Quantification Methods, Health Effects, and Molecular Mechanisms.Environment & health (Washington, D.C.) · 2026Review
- Low-Dose Occupational Exposure to Ionizing Radiation and Cardiovascular Effects: A Narrative Review.Healthcare (Basel, Switzerland) · 2024Review
- Smoking Modifies the Association Between Radon Exposure and Incident Ischemic Stroke: The REGARDS Study.Stroke · 2023Article
- Review
- Traditional and Emerging Sex-Specific Risk Factors for Cardiovascular Disease in Women.Reviews in cardiovascular medicine · 2022Review
- Early Detection of Cardiotoxicity From Systemic and Radiation Therapy in Patients With Breast Cancer: Protocol for a Multi-Institutional Prospective Study.JMIR research protocols · 2022Article
- Transcriptomic profiling reveals gene expression in human peripheral blood after exposure to low-dose ionizing radiation.Journal of radiation research · 2022Article
- Short-term metabolic disruptions in urine of mouse models following exposure to low doses of oxygen ion radiation.Journal of environmental science and health. Part C, Toxicology and carcinogenesis · 2021Article
- Radiation Response of Human Cardiac Endothelial Cells Reveals a Central Role of the cGAS-STING Pathway in the Development of Inflammation.Proteomes · 2020Article
- Ionizing Radiation-Induced Epigenetic Modifications and Their Relevance to Radiation Protection.International journal of molecular sciences · 2020Review
- Dose limits for occupational exposure to ionising radiation and genotoxic carcinogens: a German perspective.Radiation and environmental biophysics · 2020Review
- Radiation Safety and Hormesis.Frontiers in public health · 2020Article
- Radiation Risk Analysis of Neuropsychiatric Disorders in Ukrainian Chornobyl Catastrophe Liquidators.Frontiers in psychiatry · 2020Article
- An Effective Protocol for Proteome Analysis of Medaka (Methods and protocols · 2019Article
- Radiation Exposure and Mortality from Cardiovascular Disease and Cancer in Early NASA Astronauts.Scientific reports · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 6 institutions in 3 countries.
Funding
Abstract
Although the link between high doses of ionizing radiation and damage to the heart and coronary arteries has been well established for some time, the association between lower-dose exposures and late occurring cardiovascular disease has only recently begun to emerge, and is still controversial. In this paper, we extend an earlier systematic review by Little et al. on the epidemiological evidence for associations between low and moderate doses of ionizing radiation exposure and late occurring blood circulatory system disease. Excess relative risks per unit dose in epidemiological studies vary over at least two orders of magnitude, possibly a result of confounding and effect modification by well-known (but unobserved) risk factors, and there is statistically significant (p < 0.00001) heterogeneity between the risks. This heterogeneity is reduced, but remains significant, if adjustments are made for the effects of fractionated delivery or if there is stratification by endpoint (cardiovascular disease vs. stroke, morbidity vs. mortality). One possible biological mechanism is damage to endothelial cells and subsequent induction of an inflammatory response, although it seems unlikely that this would extend to low-dose and low-dose-rate exposure. A recent paper of Little et al. proposed an arguably more plausible mechanism for fractionated low-dose effects, based on monocyte cell killing in the intima. Although the predictions of the model are consistent with the epidemiological data, the experimental predictions made have yet to be tested. Further epidemiological and biological evidence will allow a firmer conclusion to be drawn.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.