Trial reportEuropean journal of nuclear medicine and molecular imaging2010
Human biodistribution and radiation dosimetry of 11C-(R)-PK11195, the prototypic PET ligand to image inflammation.
Trial report in European journal of nuclear medicine and molecular imaging, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 44 citations in OpenAlex.
- Whole body biodistribution and radiation dosimetry in humans of a new PET ligand, [(18)F]-FEPPA, to image translocator protein (18 kDa).Molecular imaging and biology · 2013Trial
- Radiation dosimetry and biodistribution of the TSPO ligand 11C-DPA-713 in humans.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2012Trial
- Biodistribution and radiation dosimetry of the 18 kDa translocator protein (TSPO) radioligand [18F]FEDAA1106: a human whole-body PET study.European journal of nuclear medicine and molecular imaging · 2011Trial
- Biodistribution and radiation dosimetry of 11C-labelled docetaxel in cancer patients.European journal of nuclear medicine and molecular imaging · 2010Trial
- First human whole-body biodistribution and dosimetry analysis of [European journal of nuclear medicine and molecular imaging · 2026Article
- A first-in-man study of [Annals of nuclear medicine · 2024Article
- Radiosynthesis and characterization of [European journal of nuclear medicine and molecular imaging · 2021Article
- Use of 55 PET radiotracers under approval of a Radioactive Drug Research Committee (RDRC).EJNMMI radiopharmacy and chemistry · 2020Article
- Integrative discovery of treatments for high-risk neuroblastoma.Nature communications · 2020Article
- Assessment of safety, efficacy, and dosimetry of a novel 18-kDa translocator protein ligand, [EJNMMI research · 2017Article
- Biodistribution of the radionuclides (18)F-FDG, (11)C-methionine, (11)C-PK11195, and (68)Ga-citrate in domestic juvenile female pigs and morphological and molecular imaging of the tracers in hematogenously disseminated Staphylococcus aureus lesions.American journal of nuclear medicine and molecular imaging · 2016Article
- In Vivo Detection of Age- and Disease-Related Increases in Neuroinflammation by 18F-GE180 TSPO MicroPET Imaging in Wild-Type and Alzheimer's Transgenic Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Promising potential of new generation translocator protein tracers providing enhanced contrast of arthritis imaging by positron emission tomography in a rat model of arthritis.Arthritis research & therapy · 2014Article
- Radiopharmaceutical stem cell tracking for neurological diseases.BioMed research international · 2014Review
- Suggested pathway to assess radiation safety of 11C-labeled PET tracers for first-in-human studies.European journal of nuclear medicine and molecular imaging · 2012Article
- Article
- Current imaging strategies in rheumatoid arthritis.American journal of nuclear medicine and molecular imaging · 2012Article
- TSPO expression in brain tumours: is TSPO a target for brain tumour imaging?Clinical and translational imagingReview
- Radiation dosimetry and biodistribution of the translocator protein radiotracer [(11)C]DAA1106 determined with PET/CT in healthy human volunteers.Nuclear medicine and biologyArticle
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe positron emission tomography (PET) radiotracer (11)C-(R)-PK11195 allows the in vivo imaging in humans of the translocator protein 18 kDa (TSPO), previously called peripheral benzodiazepine receptor (PBR), a marker of inflammation. Despite its widespread use, the radiation burden associated with (11)C-(R)-PK11195 in humans is not known. To examine this, we performed dynamic whole-body imaging with PET and (11)C-(R)-PK11195 in healthy humans.
methodsFive healthy male volunteers were scanned with PET and (11)C-(R)-PK11195, using a dynamic whole-body imaging protocol. An organ-specific method was used to measure accumulated radioactivity in source organs, and residence times were calculated as areas under the curve of time-activity curves expressed as percentage of injected radioactivity. Residence times were used as input for OLINDA/EXM 1.0 software to model the equivalent organ doses and the effective dose for the 70-kg man.
resultsAfter intravenous injection of (11)C-(R)-PK11195, radioactivity accumulated in organs rich in TSPO as well as routes of excretion: the hepatobiliary system and the urine. The mean effective dose was 4.8 microSv/MBq according to International Commission on Radiological Protection (ICRP) Publication 60 and 5.1 microSv/MBq according to ICRP Publication 103, and the highest equivalent organ doses were observed in the kidneys (14.0 microSv/MBq), spleen (12.5 microSv/MBq) and small intestine (12.2 microSv/MBq).
conclusionImaging of TSPO with PET using (11)C-(R)-PK11195 is associated with modest radiation exposure, similar in magnitude to most other (11)C-labelled PET tracers, suggesting feasibility of (11)C-(R)-PK11195 imaging in clinical human studies involving multiple scans in the same subjects per year.
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