ArticlePloS one2009
Hydrogen peroxide stimulates activity and alters behavior in Drosophila melanogaster.
Article in PloS one, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 43 citations in OpenAlex.
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- Multi-Modal Regulation of Circadian Physiology by Interactive Features of Biological Clocks.Biology · 2021Review
- The Drosophila ERG channel seizure plays a role in the neuronal homeostatic stress response.PLoS genetics · 2019Article
- Carbohydrate Metabolic Compensation Coupled to High Tolerance to Oxidative Stress in Ticks.Scientific reports · 2019Article
- Sleep and circadian defects in aNeurobiology of sleep and circadian rhythms · 2019Article
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- Flubendiamide affects visual and locomotory activities of Drosophila melanogaster for three successive generations (P, FInvertebrate neuroscience : IN · 2018Article
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- Expression of zinc-deficient human superoxide dismutase in Drosophila neurons produces a locomotor defect linked to mitochondrial dysfunction.Neurobiology of aging · 2013Article
- Early mitochondrial dysfunction leads to altered redox chemistry underlying pathogenesis of TPI deficiency.Neurobiology of disease · 2013Article
- A conserved role for the 20S proteasome and Nrf2 transcription factor in oxidative stress adaptation in mammals, Caenorhabditis elegans and Drosophila melanogaster.The Journal of experimental biology · 2013Article
- Oxidative stress adaptation with acute, chronic, and repeated stress.Free radical biology & medicine · 2013Article
- Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Circadian rhythms in animals are regulated at the level of individual cells and by systemic signaling to coordinate the activities of multiple tissues. The circadian pacemakers have several physiological outputs, including daily locomotor rhythms. Several redox-active compounds have been found to function in regulation of circadian rhythms in cells, however, how particular compounds might be involved in regulating specific animal behaviors remains largely unknown. Here the effects of hydrogen peroxide on Drosophila movement were analyzed using a recently developed three-dimensional real-time multiple fly tracking assay. Both hydrogen peroxide feeding and direct injection of hydrogen peroxide caused increased adult fly locomotor activity. Continuous treatment with hydrogen peroxide also suppressed daily locomotor rhythms. Conditional over-expression of the hydrogen peroxide-producing enzyme superoxide dismutase (SOD) also increased fly activity and altered the patterns of locomotor activity across days and weeks. The real-time fly tracking system allowed for detailed analysis of the effects of these manipulations on behavior. For example, both hydrogen peroxide feeding and SOD over-expression increased all fly motion parameters, however, hydrogen peroxide feeding caused relatively more erratic movement, whereas SOD over-expression produced relatively faster-moving flies. Taken together, the data demonstrate that hydrogen peroxide has dramatic effects on fly movement and daily locomotor rhythms, and implicate hydrogen peroxide in the normal control of these processes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.