ArticleMolecular and cellular biology1991
Regulation of heat shock factor in Schizosaccharomyces pombe more closely resembles regulation in mammals than in Saccharomyces cerevisiae.
Article in Molecular and cellular biology, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 71 citations in OpenAlex.
- Crystal structure of the Schizosaccharomyces pombe U7BR E2-binding region in complex with Ubc7.Acta crystallographica. Section F, Structural biology communications · 2019Article
- Hsp70-Hsp40 chaperone complex functions in controlling polarized growth by repressing Hsf1-driven heat stress-associated transcription.PLoS genetics · 2013Article
- hsf1 (+) extends chronological lifespan through Ecl1 family genes in fission yeast.Molecular genetics and genomics : MGG · 2011Article
- HIV-1 viral protein R (Vpr) and its interactions with host cell.Current HIV research · 2009Review
- Antagonistic interaction of HIV-1 Vpr with Hsf-mediated cellular heat shock response and Hsp16 in fission yeast (Schizosaccharomyces pombe).Retrovirology · 2007Article
- Role of glutathione in heat-shock-induced cell death of Saccharomyces cerevisiae.The Biochemical journal · 2000Article
- Mammalian SWI-SNF complexes contribute to activation of the hsp70 gene.Molecular and cellular biology · 2000Article
- Role of protein kinase C and 72 kDa heat shock protein in ischemic tolerance following heat stress in the rat heart.Molecular and cellular biochemistry · 1999Article
- Activated levels of rRNA synthesis in fission yeast are driven by an intergenic rDNA region positioned over 2500 nucleotides upstream of the initiation site.Nucleic acids research · 1997Article
- Cell cycle, DNA damage and heat shock regulate suc22+ expression in fission yeast.Molecular & general genetics : MGG · 1996Article
- The regulatory domain of human heat shock factor 1 is sufficient to sense heat stress.Molecular and cellular biology · 1996Article
- Role of chromatin and Xenopus laevis heat shock transcription factor in regulation of transcription from the X. laevis hsp70 promoter in vivo.Molecular and cellular biology · 1995Article
- The DNA-binding properties of two heat shock factors, HSF1 and HSF3, are induced in the avian erythroblast cell line HD6.Molecular and cellular biology · 1995Article
- Stress-induced transcriptional activation.Microbiological reviews · 1995Review
- Phylogenesis of fission yeasts. Contradictions surrounding the origin of a century old genus.Antonie van Leeuwenhoek · 1995Review
- The carboxyl-terminal transactivation domain of heat shock factor 1 is negatively regulated and stress responsive.Molecular and cellular biology · 1995Article
- A heat shock-responsive domain of human HSF1 that regulates transcription activation domain function.Molecular and cellular biology · 1995Article
- Fine structure analyses of the Drosophila and Saccharomyces heat shock factor--heat shock element interactions.Nucleic acids research · 1994Article
- Saccharomyces cerevisiae HSP70 heat shock elements are functionally distinct.Molecular and cellular biology · 1993Article
- Mouse heat shock transcription factors 1 and 2 prefer a trimeric binding site but interact differently with the HSP70 heat shock element.Molecular and cellular biology · 1993Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The heat shock response appears to be universal. All eucaryotes studied encode a protein, heat shock factor (HSF), that is believed to regulate transcription of heat shock genes. This protein binds to a regulatory sequence, the heat shock element, that is absolutely conserved among eucaryotes. We report here the identification of HSF in the fission yeast Schizosaccharomyces pombe. HSF binding was not observed in extracts from normally growing S. pombe (28 degrees C) but was detected in increasing amounts as the temperature of heat shock increased between 39 and 45 degrees C. This regulation is in contrast to that observed in Saccharomyces cerevisiae, in which HSF binding is detectable at both normal and heat shock temperatures. The S. pombe factor bound specifically to the heat shock element, as judged by methylation interference and DNase I protection analysis. The induction of S. pombe HSF was not inhibited by cycloheximide, suggesting that induction occurs posttranslationally, and the induced factor was shown to be phosphorylated. S. pombe HSF was purified to near homogeneity and was shown to have an apparent mobility of approximately 108 kDa. Since heat-induced DNA binding by HSF had previously been demonstrated only in metazoans, the conservation of heat-induced DNA binding by HSF among S. pombe and metazoans suggests that this mode of regulation is evolutionarily ancient.
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