ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2010
Stimulatory effects of thyroid hormone on brain angiogenesis in vivo and in vitro.
Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 62 citations in OpenAlex.
- A meta-analysis of thyroid-related traits reveals novel loci and gender-specific differences in the regulation of thyroid function.PLoS genetics · 2013Pooled it
- Maternal thyroid hormone is required to develop the hindbrain vasculature in zebrafish.Communications biology · 2025Article
- The impact of autoimmune thyroid disease on cognitive and psychiatric disorders: focus on clinical, pre-clinical and molecular studies.European thyroid journal · 2025Review
- Mapping Thyroid Hormone Action in the Human Brain.Thyroid : official journal of the American Thyroid Association · 2024Review
- Bypassing the brain barriers: upregulation of serum miR-495 and miR-543-3p reflects thyroid-mediated developmental neurotoxicity in the rat.Toxicological sciences : an official journal of the Society of Toxicology · 2024Article
- Factors and Mechanisms of Thyroid Hormone Activity in the Brain: Possible Role in Recovery and Protection.Biomolecules · 2024Review
- Neurovascular unit disruption and blood-brain barrier leakage in MCT8 deficiency.Fluids and barriers of the CNS · 2023Article
- Impact of thyroid hormone perturbations in adult mice: brain weight and blood vessel changes, gene expression variation, and neurobehavioral outcomes.Neurobiology of aging · 2023Article
- Thyroid hormone action controls multiple components of cell junctions at the ventricular zone in the newborn rat brain.Frontiers in endocrinology · 2023Article
- Effects of Thyroid Hormone on Tissue Hypoxia: Relevance to Sepsis Therapy.Journal of clinical medicine · 2021Review
- Association between thyroid-stimulating hormone (TSH) and proteinuria in relation to thyroid cyst in a euthyroid general population.Journal of physiological anthropology · 2021Article
- Review
- Thyroid hormones regulate both cardiovascular and renal mechanisms underlying hypertension.Journal of clinical hypertension (Greenwich, Conn.) · 2021Article
- Triiodothyronine potentiates angiogenesis-related factor expression through PI3K/AKT signaling pathway in human osteoarthritic osteoblasts.Iranian journal of basic medical sciences · 2020Article
- Thyroxin Protects White Matter from Hypoxic-Ischemic Insult in the Immature Sprague⁻Dawley Rat Brain by Regulating Periventricular White Matter and Cortex BDNF and CREB Pathways.International journal of molecular sciences · 2018Article
- Thyroid hormone and anti-apoptosis in tumor cells.Oncotarget · 2015Review
- Recurrence of differentiated thyroid carcinoma during full TSH suppression: is the tumor now thyroid hormone dependent?Hormones & cancer · 2015Review
- Quantitative assessment of angiogenesis, perfused blood vessels and endothelial tip cells in the postnatal mouse brain.Nature protocols · 2015Article
- Maternal thyroid hormones are essential for neural development in zebrafish.Molecular endocrinology (Baltimore, Md.) · 2014Article
- Failure of thyroid hormone treatment to prevent inflammation-induced white matter injury in the immature brain.Brain, behavior, and immunity · 2014Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Thyroid hormone is critical for the proper development of the central nervous system. However, the specific role of thyroid hormone on brain angiogenesis remains poorly understood. Treatment of rats from birth to postnatal day 21 (P21) with propylthiouracil (PTU), a reversible blocker of triiodothyronine (T3) synthesis, resulted in decreased brain angiogenesis, as indicated by reduced complexity and density of microvessels. However, when PTU was withdrawn at P22, these parameters were fully recovered by P90. These changes were paralleled by an altered expression of vascular endothelial growth factor A (Vegfa) and basic fibroblast growth factor (Fgf2). Physiologic concentrations of T3 and thyroxine (T4) stimulated proliferation and tubulogenesis of rat brain-derived endothelial (RBE4) cells in vitro. Protein and mRNA levels of VEGF-A and FGF-2 increased after T3 stimulation of RBE4 cells. The thyroid hormone receptor blocker NH-3 abolished T3-induced Fgf2 and Vegfa upregulation, indicating a receptor-mediated effect. Thyroid hormone inhibited the apoptosis in RBE4 cells and altered mRNA levels of apoptosis-related genes, namely Bcl2 and Bad. The present results show that thyroid hormone has a substantial impact on vasculature development in the brain. Pathologically altered vascularization could, therefore, be a contributing factor to the neurologic deficits induced by thyroid hormone deficiency.
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