ArticleCirculation. Heart failure2010
Effects of peripheral arterial disease on outcomes in advanced chronic systolic heart failure: a propensity-matched study.
Article in Circulation. Heart failure, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 42 citations in OpenAlex.
- Heart failure, peripheral artery disease, and dapagliflozin: a patient-level meta-analysis of DAPA-HF and DELIVER.European heart journal · 2023Pooled it
- Factors associated with hospitalisations of patients with chronic heart failure approaching the end of life: A systematic review.Palliative medicine · 2022Pooled it
- Impact of Peripheral Artery Disease in Patients With Heart Failure Undergoing Transcatheter Mitral Valve Repair: The COAPT Trial.Journal of the American Heart Association · 2023Trial
- Characteristics and outcomes of patients with advanced chronic systolic heart failure receiving care at the Veterans Affairs versus other hospitals: insights from the Beta-blocker Evaluation of Survival Trial (BEST).Circulation. Heart failure · 2015Trial
- Effect of peripheral arterial disease on functional and clinical outcomes in patients with heart failure (from HF-ACTION).The American journal of cardiology · 2011Trial
- Peripheral artery disease, chronic kidney disease, and recurrent admissions for acute decompensated heart failure: The ARIC study.Atherosclerosis · 2024Article
- Preclinical systolic dysfunction relating to ankle-brachial index among high-risk PAD population with preserved left ventricular ejection fraction.Scientific reports · 2024Article
- Association of Adherence to the Mediterranean Diet with All-Cause Mortality in Subjects with Heart Failure.Nutrients · 2022Article
- Initial diastolic dysfunction is a powerful predictor of 5-year mortality in peripheral arterial disease patients undergoing percutaneous transluminal angioplasty.Heart and vessels · 2021Article
- Recurrent Admissions for Acute Decompensated Heart Failure Among Patients With and Without Peripheral Artery Disease: The ARIC Study.Journal of the American Heart Association · 2020Article
- Independent link between peripheral artery disease and muscle wasting in patients with heart failure.ESC heart failure · 2020Article
- The CHAESC heart failure · 2016Article
- Effect of peripheral vascular disease on mortality in cardiac transplant recipients (from the United Network of Organ Sharing Database).The American journal of cardiology · 2014Article
- Peripheral arterial disease and chronic heart failure: a dangerous mix.Heart failure reviews · 2013Review
- Peripheral arterial disease of the lower extremities.Archives of medical science : AMS · 2012Article
- Impact of peripheral arterial disease on functional limitation in congestive heart failure: results from the national health and nutrition examination survey (1999-2004).Cardiology research and practice · 2012Article
- History of cancer and mortality in community-dwelling older adults.Cancer epidemiology · 2011Article
- Abdominal circumference and recurrent hospitalizations may affect the clinical outcome of patients with acute heart failure.Experimental and clinical cardiology · 2011Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundThe effect of peripheral arterial disease (PAD) on outcomes in patients with chronic heart failure (HF) has not been examined in propensity-matched studies. METHODS AND
resultsOf the 2689 patients with advanced chronic systolic HF in the Beta-Blocker Evaluation of Survival Trial, 441 had a history of PAD. Propensity scores for a history of PAD, calculated for each patient using a multivariable logistic regression model, were used to assemble a matched cohort of 299 and 1015 patients, respectively, with and without PAD who were well balanced on 65 measured baseline characteristics. Cox regression models were used to estimate hazard ratios and 95% CIs for associations between PAD and outcomes during 4.1 years of follow-up. Patients had a mean age of 63+/-11 years, 19% were women, and 19% were black. All-cause mortality occurred in 43% and 33% of patients with and without a history of PAD, respectively (hazard ratio when PAD was compared with no history of PAD, 1.40; 95% CI, 1.14 to 1.72; P=0.001). All-cause hospitalization occurred in 75% and 63% of patients with and without PAD, respectively (hazard ratio when PAD was compared with no history of PAD, 1.36; 95% CI, 1.16 to 1.58; P<0.0001). PAD-associated hazard ratios for cardiovascular mortality, HF mortality, and HF hospitalization were 1.31 (95% CI, 1.04 to 1.63; P=0.019), 1.40 (95% CI, 0.97 to 2.02; P=0.076), and 1.05 (95% CI, 0.86 to 1.29; P=0.635), respectively.
conclusionsIn a well-balanced propensity-matched population of chronic systolic HF patients, a history of PAD was independently associated with increased mortality and hospitalization.
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