ArticleThe American journal of tropical medicine and hygiene2009
Micro-positron emission tomography in the evaluation of Trypanosoma cruzi-induced heart disease: Comparison with other modalities.
Article in The American journal of tropical medicine and hygiene, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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Who cites it
13 citing papers in PubMed, 27 citations in OpenAlex.
- Use of PET/CT to detect myocardial inflammation and the risk of malignant arrhythmia in chronic Chagas disease.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023Article
- Imaging Inflammation and Infection in the Gastrointestinal Tract.International journal of molecular sciences · 2019Review
- Trypanosoma cruzi Produces the Specialized Proresolving Mediators Resolvin D1, Resolvin D5, and Resolvin E2.Infection and immunity · 2018Article
- Cardiac (18)F-FDG uptake in chagas disease.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2016Article
- Molecular imaging, biodistribution and efficacy of mesenchymal bone marrow cell therapy in a mouse model of Chagas disease.Microbes and infection · 2014Article
- High fat diet modulates Trypanosoma cruzi infection associated myocarditis.PLoS neglected tropical diseases · 2014Article
- Alterations in glucose homeostasis in a murine model of Chagas disease.The American journal of pathology · 2013Article
- Imaging of small-animal models of infectious diseases.The American journal of pathology · 2013Review
- Mesenchymal bone marrow cell therapy in a mouse model of chagas disease. Where do the cells go?PLoS neglected tropical diseases · 2012Article
- Aspirin treatment of mice infected with Trypanosoma cruzi and implications for the pathogenesis of Chagas disease.PloS one · 2011Article
- Advances in imaging of animal models of Chagas disease.Advances in parasitology · 2011Article
- Imaging the Gastrointestinal Tract of Small Animals.Journal of neuroparasitology · 2010Article
- Chagas heart disease: report on recent developments.Cardiology in reviewReview
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
Noninvasive assessment of cardiac structure and function is essential to understand the natural course of murine infection with Trypanosoma cruzi. Magnetic resonance imaging (MRI) and echocardiography have been used to monitor anatomy and function; positron emission tomography (PET) is ideal for monitoring metabolic events in the myocardium. Mice infected with T. cruzi (Brazil strain) were imaged 15-100 days post infection (dpi). Quantitative (18)F-FDG microPET imaging, MRI and echocardiography were performed and compared. Tracer ((18)F-FDG) uptake was significantly higher in infected mice at all days of infection, from 15 to 100 dpi. Dilatation of the right ventricular chamber was observed by MRI from 30 to 100 dpi in infected mice. Echocardiography revealed significantly reduced ejection fraction by 60 dpi. Combination of these three complementary imaging modalities makes it possible to noninvasively quantify cardiovascular function, morphology, and metabolism from the earliest days of infection through the chronic phase.
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