ArticleAmerican journal of physiology. Endocrinology and metabolism2010
Interactions between neurotensin and GnRH neurons in the positive feedback control of GnRH/LH secretion in the mouse.
Article in American journal of physiology. Endocrinology and metabolism, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 26 citations in OpenAlex.
- NGF administration is associated with increased GnRH immunoreactivity and a GnRH-associated phenotype in hypothalamic NSCs of aging mice.Frontiers in endocrinology · 2026Article
- Effects of Integrated Extracts ofAntioxidants (Basel, Switzerland) · 2025Article
- Decreased neurotensin induces ovulatory dysfunction via the NTSR1/ERK/EGR1 axis in polycystic ovary syndrome.Frontiers of medicine · 2025Article
- Neurotensin Expression in the Posterior Hypothalamus Is Influenced by an Increase in Kisspeptin Levels: Insights From In Vivo Rat Models and Hypothalamic Cell Models.International journal of endocrinology · 2025Article
- Neurotensin and Its Involvement in Reproductive Functions: An Exhaustive Review of the Literature.International journal of molecular sciences · 2023Review
- Estrogen differentially regulates transcriptional landscapes of preoptic and arcuate kisspeptin neuron populations.Frontiers in endocrinology · 2022Article
- Neurotensin: a neuropeptide induced by hCG in the human and rat ovary during the periovulatory period†.Biology of reproduction · 2021Article
- Neurotensin: A novel mediator of ovulation?FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2021Article
- Neurotensin and Xenin Show Positive Correlations With Perceived Stress, Anxiety, Depressiveness and Eating Disorder Symptoms in Female Obese Patients.Frontiers in behavioral neuroscience · 2021Article
- Role of central neurotensin in regulating feeding: Implications for the development and treatment of body weight disorders.Biochimica et biophysica acta. Molecular basis of disease · 2018Review
- Effect of short term diet restriction on gene expression in the bovine hypothalamus using next generation RNA sequencing technology.BMC genomics · 2017Article
- Impact of Proestrus on Gene Expression in the Medial Preoptic Area of Mice.Frontiers in cellular neuroscience · 2017Article
- KNDy Neurons Modulate the Magnitude of the Steroid-Induced Luteinizing Hormone Surges in Ovariectomized Rats.Endocrinology · 2015Article
- Interactions between kisspeptin and neurokinin B in the control of GnRH secretion in the female rat.American journal of physiology. Endocrinology and metabolism · 2011Article
- Anatomy of the kisspeptin neural network in mammals.Brain research · 2010Review
- The neurobiology of preovulatory and estradiol-induced gonadotropin-releasing hormone surges.Endocrine reviews · 2010Review
- Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
In female mammals, increased ovarian estradiol (E(2)) secretion triggers GnRH release from neurons in the basal forebrain, which drives LH secretion from the pituitary and subsequently induces ovulation. However, the neural circuits that activate this preovulatory GnRH/LH surge remain unidentified. Neurotensin is expressed in neurons of the anteroventral periventricular nucleus (AVPV), a region thought to be critical for generating the preovulatory GnRH/LH surge. E(2) induces neurotensin (Nts) gene expression in this region, and blockade of neurotensin signaling reduces the LH surge in the rat. We postulated that neurotensin signaling plays a similar role in generating the E(2)-induced GnRH/LH surge in mice. We used in situ hybridization (ISH) to determine whether E(2) induces Nts expression in the mouse and found evidence to support this proposition. Next, we determined that the neurotensin receptor (Ntsr2) is present in many GnRH-expressing neurons. Since the kisspeptin gene (Kiss1) is expressed in the AVPV and is responsive to E(2), we predicted that some neurons in this region express both Kiss1 and Nts; however, by double-label ISH, we observed no coexpression of the two mRNAs. We also postulated that Nts mRNA expression would increase in parallel with the E(2)-induced LH surge and that the central (icv) administration of neurotensin would stimulate LH secretion and activation of GnRH neurons but found no evidence to support either of these hypotheses. Together, these findings suggest that, although neurotensin neurons in the AVPV are targets for regulation by E(2), neurotensin does not appear to play a direct role in generating the GnRH/LH surge in the mouse.
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Registered trials
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