ArticleJournal of cell science2009
Increased sex chromosome expression and epigenetic abnormalities in spermatids from male mice with Y chromosome deletions.
Article in Journal of cell science, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 24 citations in OpenAlex.
- Dual role of histone variant H3.3B in spermatogenesis: positive regulation of piRNA transcription and implication in X-chromosome inactivation.Nucleic acids research · 2022Article
- Effects of the Sex Chromosome Complement, XX, XO, or XY, on the Transcriptome and Development of Mouse Oocytes During Follicular Growth.Frontiers in genetics · 2021Article
- Review
- Rescue ofGenes · 2019Article
- Mild reproductive impact of a Y chromosome deletion on a C57BL/6J substrain.Mammalian genome : official journal of the International Mammalian Genome Society · 2017Article
- Copy number variation in Y chromosome multicopy genes is linked to a paternal parent-of-origin effect on CNS autoimmune disease in female offspring.Genome biology · 2015Article
- Increased progesterone production in cumulus-oocyte complexes of female mice sired by males with the Y-chromosome long arm deletion and its potential influence on fertilization efficiency.Reproductive sciences (Thousand Oaks, Calif.) · 2015Article
- Y genetic variation and phenotypic diversity in health and disease.Biology of sex differences · 2015Article
- Lysine 2-hydroxyisobutyrylation is a widely distributed active histone mark.Nature chemical biology · 2014Article
- SSTY proteins co-localize with the post-meiotic sex chromatin and interact with regulators of its expression.The FEBS journal · 2014Article
- Sex chromosome inactivation in germ cells: emerging roles of DNA damage response pathways.Cellular and molecular life sciences : CMLS · 2012Review
- Article
- Human and mouse ZFY genes produce a conserved testis-specific transcript encoding a zinc finger protein with a short acidic domain and modified transactivation potential.Human molecular genetics · 2012Article
- Human male meiotic sex chromosome inactivation.PloS one · 2012Article
- Function of the sex chromosomes in mammalian fertility.Cold Spring Harbor perspectives in biology · 2011Review
- Deficiency in mouse Y chromosome long arm gene complement is associated with sperm DNA damage.Genome biology · 2010Article
- The multicopy gene Sly represses the sex chromosomes in the male mouse germline after meiosis.PLoS biology · 2009Article
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Authors and funding
2 authors.
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Abstract
During male meiosis, the X and Y chromosomes are transcriptionally silenced, a process termed meiotic sex chromosome inactivation (MSCI). Recent studies have shown that the sex chromosomes remain substantially transcriptionally repressed after meiosis in round spermatids, but the mechanisms involved in this later repression are poorly understood. Mice with deletions of the Y chromosome long arm (MSYq-) have increased spermatid expression of multicopy X and Y genes, and so represent a model for studying post-meiotic sex chromosome repression. Here, we show that the increase in sex chromosome transcription in spermatids from MSYq- mice affects not only multicopy but also single-copy XY genes, as well as an X-linked reporter gene. This increase in transcription is accompanied by specific changes in the sex chromosome histone code, including almost complete loss of H4K8Ac and reduction of H3K9me3 and CBX1. Together, these data show that an MSYq gene regulates sex chromosome gene expression as well as chromatin remodelling in spermatids.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.